| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
DMSO/Tf2O Mediated one-pot construction of 3a-substituted pyrroloindole framework has been developed. In investigation of a variety of nucleophiles, the synthetic method of 3-(1-indolyl)pyrroloindole framework with indoline nucleus has been developed, which was applied in total synthesis of (±)-psychotriasine.
In the case of tryptamine nucleophile, one-pot synthesis of bisquaternary carbon containing bispyrroloindole core has been achieved. Furthermore, the first one-pot heterodimerization has been successfully developed with tryptamine derivative which was different from starting one.
In addition, enantioselective synthetic method has been achieved with newly designed C2-symmetric chiral sulfoxide. The synthetic utility of this method was declared through the enantioselective total synthesis of (+)-psychotriasine.
|
