Analysis of soluble and labile chemical species changes using time dependent cold-spray ionization mass spectrometry
| Project/Area Number |
25860033
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
OHARA Kazuaki 徳島文理大学, 薬学部, 助教 (60581775)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | コールドスプレーイオン化 / ソフトイオン化 / 配位オリゴマー / 錯形成反応追跡 / 帰属 / 配位高分子 / 組成式解析 / CSI-MS / 質量分析 / 錯体 |
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| Outline of Final Research Achievements |
Cold-spray ionization mass spectrometry (CSI-MS) is a soft ionization method to ionize chemical species constructed with weak interaction without fragmentation. In this study, several coordination species were detected by CSI-MS in complexation. Two different ligands solutions were mixed at different ratios and metal solution was added to their ligands solutions, and then coordination complexes were synthesized. After crystallization by adding a poor solvent to the solutions, two different crystals were obtained at two different ratios．This fact indicated that ion peaks change of CSI-MS was related to a crystalline structure change. In addition, it was found that component-composition analysis could effectively assign the ion peaks detected in soft ionization.
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Report
(3 results)
Research Products
(19 results)
