Development of new anti-HIV drug lead from anti-HIV natural product biyouyanagin A
| Project/Area Number |
25860074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | The University of Tokushima (2014)
Hokkaido University (2013) |
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Principal Investigator |
TANAKA Naonobu 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (40455598)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 抗HIV薬リード / 天然物 / ビヨウヤナギンA / 抗HIV活性物質 / 天然物質 |
|---|
| Outline of Final Research Achievements |
Precursors for analogues of an anti-HIV natural product, biyouyanagin A, were prepared from natural sources. Bromopyrrole alkaloids (from a marine sponge of Agelas sp.), oxylipins (Plakortis sp.), indole alkaloids (Hyrtios sp.), secoiridoid glucosides (from Gentiana plant) and diterpenes (from Isodon plant) were isolated from marine sponges and plants as precursors of the terpenoid moiety, while hyperolactones were isolated from a plant Hypericum chinense as precursors of spirolactone moiety. Some biyouyanagin A analogues were obtained from bromopyrrole alkaloids and hyperolactones by the [2+2] photocycloaddition reaction.
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] Prenylated benzophenones from Triadenum japonicum2015
Author(s)
Oya, A.; Tanaka, N.; Kusama, T.; Kim, S.-Y.; Hayashi, S.; Kojoma, M.; Hishida, A.; Kawahara, N.; Sakai, K.; Gonoi, T.; Kobayashi, J.
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Journal Title
J. Nat. Prod.
Volume: 78
Issue: 2
Pages: 258-264
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Meroterpenoids from Hypericum plants2014
Author(s)
Tanaka, N.; Kobayashi, J.; Kashiwada, Y.
Organizer
2014 Annual meeting of the American society of pharmacognosy
Place of Presentation
Oxford Conference Center, Oxford, MS, US.
Year and Date
2014-08-04
Related Report
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[Presentation] Studies on medicinal plants of Yunnan province: constituents of Gentiana rigescens2014
Author(s)
Suyama, Y.; Tanaka, N.; Kurimoto, S.-I.; Kawazoe, K.; Murakami, K.; Sun, H. D.; Li, S. L.; Takaishi, Y.; Kashiwada, Y.
Organizer
2014 Annual meeting of the American society of pharmacognosy
Place of Presentation
Oxford Conference Center, Oxford, MS, US.
Year and Date
2014-08-04
Related Report
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