| Project/Area Number |
25860082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 抗マラリア原虫活性 / 抗生物質 / 抗マラリア原虫活性物質 / Glyoxalase I |
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| Outline of Final Research Achievements |
Malaria is the one of most devastating infectious diseases caused by Plasmodium parasite. It is urgently necessary to develop new drugs, which should be effective to drug-resistant strains, be safer, be cheaper, and be used orally. In order to discover seed compounds for new antimalarial drugs, we conducted the screening of active compounds, guided by antimalarial activity as well as inhibitory activity of glyoxalase I (PfGLOI). As a result, we identified 2 known compounds and 1 possibly new compounds as antimalarial agents form 3 fungal cultured broths. We identified 1 known compounds and 1 possibly new compounds as PfGLOI inhibitors form 2 fungal cultured broths.
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