| Project/Area Number |
25860106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
DOKI Kosuke 筑波大学, 医学医療系, 講師 (90620881)
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| Research Collaborator |
HOMMA MASATO 筑波大学, 医学医療系, 教授
AONUMA KAZUTAKA 筑波大学, 医学医療系, 教授
KUGA KEISUKE 筑波大学, 医学医療系, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心筋ナトリウムチャネル / ナトリウムチャネル遮断薬 / 遺伝子多型 / β1アドレナリン受容体 / 遺伝子変異 / フレカイニド / プロパフェノン / 有効血中濃度 / SCN5A / β1受容体 / β１受容体 |
|---|
| Outline of Final Research Achievements |
Inter-individual variability in anti-arrhythmic efficacy of sodium channel blockers was examined on the basis of cardiac sodium channel-related gene polymorphism analysis. Asian-specific promoter haplotype of the cardiac sodium channel gene was associated with effectiveness in lower concentration of sodium channel blockers. β1-adrenergic receptor polymorphism led to reduced anti-arrhythmic efficacy of sodium channel blocker. These findings suggest that cardiac sodium channel-related gene polymorphisms are important for dose adjustment of sodium channel blockers.
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