The effect of anticancer agent induced gastrointestinal damage on drug absorption

Research Project

Project/Area Number	25860125
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Medical pharmacy
Research Institution	Keio University
Principal Investigator	AKIYOSHI TAKESHI 慶應義塾大学, 薬学部, 助教 (50399143)
Research Collaborator	TSUJII Kazunari YOTSUMOTO Keiichi
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	消化管障害 / 5-FU / ダビガトラン / 抗癌剤 / 体内動態 / アルミニウム定量法 / 難吸収性マーカー
Outline of Final Research Achievements	We evaluated the effects of 5-FU induced gastrointestinal damage on dabigatran pharmacokinetics(PK) and pharmacodynamics(PD) in rats. After oral administration of DABE, the PK parameters of Cmax and AUC of DAB in the 5-FU group were decreased by 30% compared to that of control group. Moreover, the PD parameter of activated partial thromboplastin time (aPTT) in the 5-FU group was also reduced. We concluded that intensive monitoring of DABE PK/PD under treatment with 5-FU is required.