| Project/Area Number |
25860143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Ehime University |
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Principal Investigator |
HARAGUCHI Ryuma 愛媛大学, 医学(系)研究科(研究院), 講師 (00423690)
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| Research Collaborator |
KITAZAWA Sohei 愛媛大学, 大学院医学系研究科, 教授 (90186239)
KITAZAWA Riko 愛媛大学, 医学部附属病院, 准教授 (00273780)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 雌性生殖器 / ヘッジホッグ / 組織系譜 / 遺伝子改変マウス / ミュラー管 / ウォルフ管 / Shhシグナル / Genetic Lineage Tracing法 / 雄性生殖管 / 子宮 |
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| Outline of Final Research Achievements |
In the female reproductive tract (FRT) formation, mullerian duct is a necessary for FRT derevative organs, which are the uterus and part of the vagina. On the other hand, there is also the opinion that male reproductive duct, a Wolffian duct, is required for female reproductive organs. In this research, we revealed that Shh signaling derived from Wolffian duct acts as a signaling molecule organizing FRT formation.In addition, by fate mapping studies using genetic lineage tracing method, we revealed that Shh sigunal responding cells directly contribut to uterus development.
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