| Project/Area Number |
25860147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下垂体前葉 / 濾胞星状細胞 / 3次元培養 / 細胞外マトリックス / コラーゲン / ラミニン / 組織構築 / TGFbeta |
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| Outline of Final Research Achievements |
Aim of this project is to decipher a role of folliculostellate cells in tissue formation of anterior pituitary gland. This project utilized a 3 dimensional cell culture of rat anterior pituitary cells established by our laboratory, and S100b-GFP transgenic rats that express GFP in folliclulostellate cells. This project found 1) folliculostellate cells are required for release of major basement membrane component, laminin, from goandotrophs, and 2) TGFb2 secreted from folliculostellate cells induces collagen synthesis of microvessel mural cells, pericytes. In conclusion, this project revealed a novel function of folliculostellate cells, namely, a regulation of extracellular matrix within anterior pituitary gland.
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