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The roles of (pro)renin receptor in cerebral, cardiac and renal diseases

Research Project

Project/Area Number 25860156
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionTohoku University

Principal Investigator

HIROSE Takuo  東北大学, 医学(系)研究科(研究院), 助教 (20599302)

Research Collaborator IMAI Yutaka  東北大学, 大学院薬学研究科, 教授 (40133946)
TOTSUNE Kazuhito  東北大学, 大学院薬学研究科, 客員教授 (10217515)
TAKAHASHI Kazuhiro  東北大学, 大学院医学系研究科, 教授 (80241628)
MORI Takefumi  東北大学, 大学院医学系研究科, 准教授 (40375001)
GENEVIEVE Nguyen  College de France, Center for Interdisciplinary Research in Biology, Director
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords(プロ)レニン受容体 / レニン・アンジオテンシン系 / 生理活性物質 / 発生 / 組織障害 / 生理活性 / 発現・制御 / 細胞・組織 / 脳・神経
Outline of Final Research Achievements

The aim of this study is to clarify the roles of (pro)renin receptor in cerebral, cardiac and renal diseases. We have generated muntant mice carrying a conditional deletion in brain cortex. The mutant mice displayed a flattened forehead corresponding with a lack of nearly their entire cortex. (pro)renin receptor regulate lysosomal pH via V-ATPase membrane assembly and relate to autophagy. We also showed that plasma concentration of soluble (pro)renin receptor is independent of plasma renin, prorenin and aldosterone concentrations and that plasma (pro)renin receptor concentration is increased in the patients of congestive heart failure, chronic renal failure and pancreatic cancer.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] A functional (pro)renin receptor is expressed in human lymphocytes and monocytes.2015

    • Author(s)
      Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 308 Issue: 5 Pages: F487-F499

    • DOI

      10.1152/ajprenal.00206.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma.2015

    • Author(s)
      Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, Masaki T, Suzuki Y, Yachida S, Nishiyama A.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 8854-8854

    • DOI

      10.1038/srep08854

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of aldosterone-to-renin ratio with hypertension differs by sodium intake: The ohasama study2015

    • Author(s)
      Satoh M, Kikuya M, Hosaka M, et al.
    • Journal Title

      Am J Hypertens.

      Volume: 28 Issue: 2 Pages: 208

    • DOI

      10.1093/ajh/hpu115

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of (pro)renin receptor in breast cancers and its effect on cancercell proliferation2014

    • Author(s)
      Koji Ohba, Takashi Suzuki, Hiroshi Nishiyama, Kiriko Kaneko, Takuo Hirose, Kazuhito Totsune, Hironobu Sasano, Kazuhiro Takahashi.
    • Journal Title

      Biomedical Research

      Volume: 35 Issue: 2 Pages: 117-126

    • DOI

      10.2220/biomedres.35.117

    • NAID

      130004470857

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity.2014

    • Author(s)
      Nguyen G, Blanchard A, Curis E, Bergerot D, Chambon Y, Hirose T, Caumont-Prim A, Tabard SB, Baron S, Frank M, Totsune K, Azizi M.
    • Journal Title

      Hypertension

      Volume: 63 Issue: 2 Pages: 297-302

    • DOI

      10.1161/hypertensionaha.113.02217

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 中枢における(プロ)レニン受容体の機能解析2015

    • Author(s)
      廣瀬卓男、Alfredo Cabrera-Soccoro、金子桐子、Jeanne d’Arc Al Bacha、Oliver Feraud、Annelise Bennaceur-Griscelli、Charles E. Schwartz、伊藤貞嘉、Matthias Groszer、Genevieve Nguyen.
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京(千代田区)
    • Year and Date
      2015-04-23 – 2015-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] The (pro)renin receptor and brain development2014

    • Author(s)
      Takuo Hirose, Alfredo Cabrera Soccoro, David Chitayat, Kiriko Kaneko, Jeanne d’Arc Al Bacha, Olivier Féraud, Annelise Bennaceur-Griscelli, Charles E. Schwartz, Matthias Groszer, Genevieve Nguyen
    • Organizer
      Gordon Research Conference Angiotensin
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト血中プロレニン受容体様免疫活性物質の検討2013

    • Author(s)
      Alfredo Cabrera Soccoro, Takuo Hirose, Olivier Féraud, Carmen Cifuentes-Diaz, David Chitayat, Annelise Bennaceur-Griscelli, Charles E Schwartz, Genevieve Nguyen, Matthias Groszer
    • Organizer
      第17回日本心血管内分泌代謝学会
    • Place of Presentation
      豊中市
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional Characterization of a Novel Candicate Gene for X-linked Intellectual Disability2013

    • Author(s)
      Alfredo Cabrera Soccoro, Takuo Hirose, Olivier Féraud, Carmen Cifuentes-Diaz, David Chitayat, Annelise Bennaceur-Griscelli, Charles E Schwartz, Genevieve Nguyen, Matthias Groszer
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] (プロ)レニン受容体とWntシグナル2013

    • Author(s)
      廣瀬卓男, Genevieve Nguyen
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 実はすごい!ACE阻害薬~エキスパートからの50のアドバイス~ I-1. レニン―アンジオテンシン(RA)系とアンジオテンシンI変換酵素(ACE)にかんしてわかりやすく説明して下さい2015

    • Author(s)
      廣瀬卓男、大久保孝義
    • Total Pages
      370
    • Publisher
      南江堂
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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