The roles of (pro)renin receptor in cerebral, cardiac and renal diseases
Project/Area Number |
25860156
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General physiology
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Research Institution | Tohoku University |
Principal Investigator |
HIROSE Takuo 東北大学, 医学(系)研究科(研究院), 助教 (20599302)
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Research Collaborator |
IMAI Yutaka 東北大学, 大学院薬学研究科, 教授 (40133946)
TOTSUNE Kazuhito 東北大学, 大学院薬学研究科, 客員教授 (10217515)
TAKAHASHI Kazuhiro 東北大学, 大学院医学系研究科, 教授 (80241628)
MORI Takefumi 東北大学, 大学院医学系研究科, 准教授 (40375001)
GENEVIEVE Nguyen College de France, Center for Interdisciplinary Research in Biology, Director
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | (プロ)レニン受容体 / レニン・アンジオテンシン系 / 生理活性物質 / 発生 / 組織障害 / 生理活性 / 発現・制御 / 細胞・組織 / 脳・神経 |
Outline of Final Research Achievements |
The aim of this study is to clarify the roles of (pro)renin receptor in cerebral, cardiac and renal diseases. We have generated muntant mice carrying a conditional deletion in brain cortex. The mutant mice displayed a flattened forehead corresponding with a lack of nearly their entire cortex. (pro)renin receptor regulate lysosomal pH via V-ATPase membrane assembly and relate to autophagy. We also showed that plasma concentration of soluble (pro)renin receptor is independent of plasma renin, prorenin and aldosterone concentrations and that plasma (pro)renin receptor concentration is increased in the patients of congestive heart failure, chronic renal failure and pancreatic cancer.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] A functional (pro)renin receptor is expressed in human lymphocytes and monocytes.2015
Author(s)
Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
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Journal Title
Am J Physiol Renal Physiol.
Volume: 308
Issue: 5
Pages: F487-F499
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma.2015
Author(s)
Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, Masaki T, Suzuki Y, Yachida S, Nishiyama A.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 8854-8854
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity.2014
Author(s)
Nguyen G, Blanchard A, Curis E, Bergerot D, Chambon Y, Hirose T, Caumont-Prim A, Tabard SB, Baron S, Frank M, Totsune K, Azizi M.
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Journal Title
Hypertension
Volume: 63
Issue: 2
Pages: 297-302
DOI
Related Report
Peer Reviewed
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[Presentation] The (pro)renin receptor and brain development2014
Author(s)
Takuo Hirose, Alfredo Cabrera Soccoro, David Chitayat, Kiriko Kaneko, Jeanne d’Arc Al Bacha, Olivier Féraud, Annelise Bennaceur-Griscelli, Charles E. Schwartz, Matthias Groszer, Genevieve Nguyen
Organizer
Gordon Research Conference Angiotensin
Place of Presentation
Lucca, Italy
Related Report
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[Presentation] ヒト血中プロレニン受容体様免疫活性物質の検討2013
Author(s)
Alfredo Cabrera Soccoro, Takuo Hirose, Olivier Féraud, Carmen Cifuentes-Diaz, David Chitayat, Annelise Bennaceur-Griscelli, Charles E Schwartz, Genevieve Nguyen, Matthias Groszer
Organizer
第17回日本心血管内分泌代謝学会
Place of Presentation
豊中市
Related Report
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