An analysis of TMEM16F KO mice as the model of Scott Syndrome
| Project/Area Number |
25860162
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
FUJII Toshihiro 京都大学, 医学(系)研究科(研究院), 助教 (30580104)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | TMEM16F / 血小板 / スコット症候群 / in vivo イメージング / phosphatidylserine / Scott症候群 / ホスファチジルセリン / 血液凝固 / 血栓 / マイクロパーティクル |
|---|
| Outline of Final Research Achievements |
TMEM16F was found a Ca2+-dependent phospholipid scramblase and a point mutation of TMEM16F from patient with Scott syndrome, a mild bleeding disorder. We investigated TMEM16F-deficient mice. Here we describe the phenotypes of platelet-specific TMEM16F-null mice, which resemble those of Scott syndrome patients. Platelets from these mice exhibit defects in PS exposure, microparticle release, and tissue factor-induced thrombin generation in vitro and in vivo.
|
Report
(3 results)
Research Products
(3 results)
-
[Journal Article] Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members.2013
Author(s)
Suzuki, J., Fujii, T., Imao, T., Ishihara, K., Kuba, H. and Nagata, S.
-
Journal Title
J Biol Chem.
Volume: 288
Issue: 19
Pages: 13305-13316
DOI
NAID
Related Report
Peer Reviewed
-
-
