| Project/Area Number |
25860162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJII Toshihiro 京都大学, 医学(系)研究科(研究院), 助教 (30580104)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | TMEM16F / 血小板 / スコット症候群 / in vivo イメージング / phosphatidylserine / Scott症候群 / ホスファチジルセリン / 血液凝固 / 血栓 / マイクロパーティクル |
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| Outline of Final Research Achievements |
TMEM16F was found a Ca2+-dependent phospholipid scramblase and a point mutation of TMEM16F from patient with Scott syndrome, a mild bleeding disorder. We investigated TMEM16F-deficient mice. Here we describe the phenotypes of platelet-specific TMEM16F-null mice, which resemble those of Scott syndrome patients. Platelets from these mice exhibit defects in PS exposure, microparticle release, and tissue factor-induced thrombin generation in vitro and in vivo.
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