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Physiological roles of TRPM2 in microglial functions

Research Project

Project/Area Number 25860172
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKyoto Prefectural University of Medicine (2014)
Okazaki Research Facilities, National Institutes of Natural Sciences (2013)

Principal Investigator

KASHIO Makiko  京都府立医科大学, 医学(系)研究科(研究院), 助教 (20631394)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsTRPM2 / レドックスシグナル / 温度 / インスリン
Outline of Final Research Achievements

Pancreatic b-cells secrete hypoglycemic insulin upon blood glucose elevation to keep its concentration in the range of physiological levels. Insulin secretion from pancreatic b-cell is well known to be mediated by KATP channel-dependent canonical pathway in which KATP channel closure by intracellular ATP elevation causes membrane depolarization and activation of voltage-dependent Ca channel. However, beside the canonical pathway, KATP channel-independet pathways are recently elucidated to be involved in insulin secretion. As one of them, we have clarified the involvement of TRPM2 function in insulin secretion focusing on redox signal-mediated TRPM2-sensitization leading its activation at body temperature.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (2 results) Book (2 results)

  • [Journal Article] Redox signal-mediated enhancement of the temperature sensitivity of Transient Receptor Potential Melastatin 2 (TRPM2) elevated glucose-induced insulin secretion from pancreatic islets.2015

    • Author(s)
      Makiko Kashio and Makoto Tominaga
    • Journal Title

      J Biol Chem

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Propofol-induced pain sensation involves multiple mechanisms in sensory neurons.2015

    • Author(s)
      Rei Nishimoto, Makiko Kashio, Makoto Tominaga
    • Journal Title

      Pflugers Arch

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia2015

    • Author(s)
      Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Mizuno A, Suzuki M, Yamashita Y, Masuko S, Goto M, Tominaga M, Kido MA
    • Journal Title

      The FASEB Journal

      Volume: 29 Issue: 1 Pages: 182-192

    • DOI

      10.1096/fj.14-251314

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.2014

    • Author(s)
      Banzawa N1, Saito S2, Imagawa T., Kashio M., Takahashi K., Tominaga M. and Ohta T.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 46 Pages: 31927-31939

    • DOI

      10.1074/jbc.m114.586891

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison.2014

    • Author(s)
      Saito S, Banzawa N, Fukuta N, Saito T.C., Takahashi K, Imagawa T, Ohta T, Tominaga M.
    • Journal Title

      Molec. Biol. Evol.

      Volume: 31(3) Issue: 3 Pages: 708-722

    • DOI

      10.1093/molbev/msu001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness.2013

    • Author(s)
      H. Ota, K. Katanosaka, S. Murase, M. Kashio, M. Tominaga, and K. Mizumura.
    • Journal Title

      PLoS.ONE

      Volume: 8 Issue: 6 Pages: e65751-e65751

    • DOI

      10.1371/journal.pone.0065751

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Redox signal-mediated sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to temperatures affects insulin secretion from the pancreatic b-cells2015

    • Author(s)
      加塩麻紀子、丸中良典、富永真琴
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] レドックスシグナルによるTRPM2感作は膵臓β細胞からのインスリン分泌を調節する

    • Author(s)
      加塩麻紀子、森泰生、富永真琴
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県・鹿児島市・鹿児島大学
    • Related Report
      2013 Research-status Report
  • [Book] 臨床免疫・アレルギー科2014

    • Author(s)
      加塩麻紀子、富永真琴
    • Total Pages
      5
    • Publisher
      科学評論社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学2014年3月号「体温センサーとしてのTRPチャネル」2014

    • Author(s)
      加塩麻紀子、富永真琴
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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