Mechanisms of autonomic nervous system development and responses to environmental stresses
Project/Area Number |
25860177
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | The University of Tokyo |
Principal Investigator |
Asaka Tomomi 東京大学, 新領域創成科学研究科, 特任研究員 (90555707)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | メダカ / 発達 / 自律神経系 / 心臓 / 自律神経 / 環境応答 |
Outline of Final Research Achievements |
This study was focused on the evaluation of activity of the cardiac autonomic nervous system using medaka as a model organism and analyzed the acquirement process of the cardiac autonomic nerve function, establishment of the condition of environmental disturbance and its analysis. Development of cardiac autonomic nervous function starts from the hatching stage and the activity grows in one month old larvae. Low temperature stimulation caused arrhythmia in some medaka strains of heart beat initiation period indicating this cold sensitivity is attribute to single gene. Parasympathetic nervous activity decreased after the continuous photoperiod, however, radiation stimulation did not cause the abnormal heartbeat using the environmental disturbance system. Furthermore, establishment and preliminary analysis of the blood and the 3D analysis of tissues suggests usefulness of medaka as model organism.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Histological and transcriptomic analysis of adult Japanese medaka sampled onboard the international space station2015
Author(s)
Yasuhiko Murata, Takako Yasuda, Tomomi Watanabe-Asaka, Shoji Oda, Akiko, Mantoku, Kazuhiro Takeyama, Masahiro Chatani, Akira Kudo, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Masaki Shirakawa, Koichi Fujisawa, Yoshihiko, Hamamoto, *Shuji Terai, *Hiroshi Mitani
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Journal Title
PLOS ONE
Volume: 10
Issue: 10
Pages: e0138799-e0138799
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Availability of Medaka as Systemic Effect Model of Local Irradiation by Histological Analysis2015
Author(s)
Tomomi Watanabe-Asaka, Kazusa Ito, Chika Hashimoto, Takako Yasuda, Kento Nagata, Toshiyuki Nishimaki, Takafumi Katsumura, Hiroki Oota, Hiroko Ikeda, Yuichiro Yokota, Tetsuya Sakashita, Michiyo Suzuki, Tomoo Funayama, Yasuhiko Kobayashi, Shoji Oda, and Hiroshi Mitani
Organizer
15th International Congress of Radiation Research
Place of Presentation
京都国際会館(京都府京都市)
Year and Date
2015-05-24
Related Report
Int'l Joint Research
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[Presentation] Investigation of somatic acute responses induced by local irradiation in adult medaka2014
Author(s)
Chika Hashimoto, Tomomi Watanabe-Asaka, Takako Yasuda, Hisako Oonishi, Toshiyuki Nishimaki, Takafumi Katsumura, Hiroki Oota, Hiroko Ikeda, Yuichiro Yokota, Michiyo Suzuki, Tomoo Funayama, Yasuhiko Kobayashi, Shoji Oda, and Hiroshi Mitani
Organizer
The 20th Japanese Medaka and Zebrafish Meeting
Place of Presentation
慶応大学(東京都港区)
Year and Date
2014-09-20 – 2014-09-21
Related Report
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