Roles of human REG family genes in pancreatic beta cell regeneration
Project/Area Number |
25860220
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Nara Medical University |
Principal Investigator |
YAMAUCHI AKIYO 奈良県立医科大学, 医学部, 助教 (70361110)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 再生増殖因子 / SNP |
Outline of Final Research Achievements |
REG family genes are considered to be involved in pancreatic β cell regeneration. In human, 5 REG genes were isolated. However, which human REG gene is expressed in β cells during inflammation is unclear. In this study, it was revealed that among 5 human REG genes, REG Iα and REG Iβ were induced under an inflammatory condition through JAK/STAT pathway. The effects of the -563G/A and -10T/C polymorphisms in the REG Iα promoter as well as the -231G/A and -165A/C polymorphisms in the REG Iβ promoter on the induction were examined. As a result, in cells transfected with the constructs containing the minor allele, the fold increases of promoter activity by inflammation were significantly reduced.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Significance of interleukin-6/STAT pathway for the gene expression of REG Iα, a new autoantigen in Sjogren’s syndrome patients, in salivary duct epithelial cells.2016
Author(s)
Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Sakuramoto-Tsuchida S, Yamauchi A, Takeda M, Tsujinaka H, Tanaka Y, Takasawa S.
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Journal Title
Clin. Rev. Allergy Immunol.
Volume: -
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjogren’s syndrome patients,in salivary duct epithelial cells.2015
Author(s)
Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Yamauchi A, Sakuramoto-Tsuchida S, Kondo S, Takeda M, Tsujinaka H, Azuma M, Tanaka Y, Takasawa S.
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Journal Title
Biochem. Biophys. Rep.
Volume: 2
Pages: 69-74
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synergistic activations of REG Iα and REG Iβ promoters by IL-6 and glucocorticoids through JAK/STAT pathway in human pancreatic β cells2015
Author(s)
Yamauchi A, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takeda M, Yoshimoto K, Miyaoka T, Fujimura T, Tsujinaka H, Tsuchida C, Ota H, Takasawa S
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Journal Title
J. Diabetes Res.
Volume: 2015
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression of Ins1 and Ins2 genes in mouse fetal liver2014
Author(s)
Murakami-Kawaguchi S, Takasawa S, Onogawa T, Nata K, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Ota H, Takeda M, Kato M, Okamoto H.
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Journal Title
Cell Tissue Res.
Volume: 355
Issue: 2
Pages: 303-314
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjogren's syndrome.2013
Author(s)
Yoshimoto K, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Sakuramoto-Tsuchida S, Yamauchi A, Takeda M, Kasai T, Nakagawara K, Nonomura A, Takasawa S.
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Journal Title
Clin. Exp. Immunol.
Volume: 174
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of REG III and prognosis in head and neck cancer.2013
Author(s)
Masui T, Ota I, Itaya-Hironaka A, Takeda M, Kasai T, Yamauchi A, Sakuramoto-Tsuchida S, Mikami S, Yane K, Takasawa S, Hosoi H.
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Journal Title
Oncol. Rep.
Volume: 30
Issue: 2
Pages: 573-578
DOI
Related Report
Peer Reviewed
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[Journal Article] Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation.2013
Author(s)
Nakagawa K, Takasawa S, Nata K, Yamauchi A, Itaya-Hironaka A, Ota H, Yoshimoto K, Sakuramoto-Tsuchida S, Miyaoka T, Takeda M, Unno M, Okamoto H.
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Journal Title
Biochim. Biophys. Acta-Molecular Cell Research
Volume: 1833
Issue: 12
Pages: 2988-2995
DOI
Related Report
Peer Reviewed
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[Journal Article] Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene.2013
Author(s)
Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Miyaoka T, Fujimura T, Tsujinaka H, Yoshimoto K, Nakagawara K-I, Tamaki S, Takasawa S, Kimura H.
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Journal Title
Life Sci.
Volume: 93
Issue: 18-19
Pages: 664-672
DOI
Related Report
Peer Reviewed
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[Presentation] Up-regulation of selenoprotein P, and HIP/PAP in hepatocytes by cyclic intermittent hypoxia.2016
Author(s)
Ota H, Yamauchi M, Koyama N, Fujita Y, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Shobatake R, Tomoda K, Yoshikawa M, Takasawa S, Kimura H.
Organizer
American Thoracic Society International Conference 2016
Place of Presentation
San Francisco (U.S.A.)
Year and Date
2016-05-13
Related Report
Int'l Joint Research
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[Presentation] Cyclic intermittent hypoxia up-regulated mRNAs of selenoprotein P and HIP/PAP.2016
Author(s)
Ota H, Yamauchi M, Tomoda K, Koyama N, Fujita Y, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Takasawa S, Yoshikawa M, Kimura H.
Organizer
The 56th Annual Meeting of the Japanese Respiratory Society
Place of Presentation
国立京都国際会館(京都)
Year and Date
2016-04-08
Related Report
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[Presentation] Up-regulation of selenoprotein P, a diabetes-associated hepatokine, and HIP/PAP, a mitogenic factor for liver, in hepatocytes by intermittent hypoxia.2015
Author(s)
Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Fujimura T, Tsujinaka, H, Tomoda K, Yoshikawa M, Kimura H, Takasawa S.
Organizer
51st European Association for the Study of Diabetes
Place of Presentation
Stockholm (Sweden)
Year and Date
2015-09-14
Related Report
Int'l Joint Research
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[Presentation] Combined stimulation of IL-6 and dexamethasone activated human REG Iα and REG Iβ gene transcription in human pancreatic β cells via the JAK/STAT signaling pathway.2015
Author(s)
Yamauchi A, Itaya-Hironaka A, Sakutamoto-Tsuchida S, Takeda M, Yoshimoto K, Miyaoka T, Fujimura T, Tsujinaka H, Tsuchida C, Ota H, Takawasa S
Organizer
American Diabetes Association 75th Scientific Sessions
Place of Presentation
Boston (U.S.A.)
Year and Date
2015-06-05 – 2015-06-09
Related Report
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[Presentation] Expression of proinsulin genes in fetal liver2014
Author(s)
Takasawa S, Murakami-Kawaguchi S, Nata K, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Ota H, Takeda M, Tsuchida C, Tsujinaka H, Fujimura T, Okamoto H.
Organizer
50th European Association for the Study of Diabetes
Place of Presentation
Vienna (Austria)
Year and Date
2014-09-15 – 2014-09-19
Related Report
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[Presentation] Combined addition of interleukin-6 and dexamethasone prevented Reg protein-induced β cell apoptosis through activation of HGF gene transcription.2014
Author(s)
Takasawa S, Nakagawa K, Nata K, Yamauchi A, Itaya-Hironaka A, Ota H, Sakuramoto-Tsuchida S, Miyaoka T, Takeda M, Fujimura T, Tsujinaka H, Unno M, Okamoto H
Organizer
American Diabetes Association 74th Scientific Sessions
Place of Presentation
San Francisco (U.S.A.)
Year and Date
2014-06-13 – 2014-06-17
Related Report
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[Presentation] Interleukin-6/STAT pathway is responsible for the induction of REG Iα, a new auto-antigen in Sjogren’s syndrome patients, in salivary duct epithelial cells.2014
Author(s)
Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Kondo S, Yoshimoto K, Sakuramoto-Tsuchida S, Yamauchi A, Tsujinaka H, Tanaka Y, Takasawa S
Organizer
Annual European Congress of Rheumatology EULAR 2014
Place of Presentation
Paris (France)
Year and Date
2014-06-11 – 2014-06-14
Related Report
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[Presentation] Induction of REG Iα, a new auto-antigen in Sjogren’s syndrome patients, in salivary duct epithelial cells by interleukin-6 and -11.2013
Author(s)
Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Sakuramoto-Tsuchida S, Yamauchi A, Tsujinaka H, Tanaka Y, Takasawa S.
Organizer
Annual European Congress of Rheumatology EULAR 2013
Place of Presentation
Madrid, Spain
Related Report
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[Presentation] Dysfunction and proliferation of pancreatic beta cells by intermittent hypoxia.2013
Author(s)
Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Takeda M, Fujimura T, Tsujinaka H, Tsuchida C, Tamaki S, Takasawa S, Kimura H.
Organizer
World Diabetes Congress 2013
Place of Presentation
Melbourne, Australia
Related Report
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[Book] Pancreatic Islet Biology2015
Author(s)
Takasawa S, Itaya-Hironaka A, Yamauchi A, Ota H, Takeda M, Sakuramoto-Tsuchida S, Fujimura T, Tsujinaka H
Publisher
Springer, Berlin
Related Report