| Project/Area Number |
25860220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
YAMAUCHI AKIYO 奈良県立医科大学, 医学部, 助教 (70361110)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 再生増殖因子 / SNP |
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| Outline of Final Research Achievements |
REG family genes are considered to be involved in pancreatic β cell regeneration. In human, 5 REG genes were isolated. However, which human REG gene is expressed in β cells during inflammation is unclear. In this study, it was revealed that among 5 human REG genes, REG Iα and REG Iβ were induced under an inflammatory condition through JAK/STAT pathway. The effects of the -563G/A and -10T/C polymorphisms in the REG Iα promoter as well as the -231G/A and -165A/C polymorphisms in the REG Iβ promoter on the induction were examined. As a result, in cells transfected with the constructs containing the minor allele, the fold increases of promoter activity by inflammation were significantly reduced.
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