Polycomb and Trithorax complexes control epigenetic memory of T helper cells
Project/Area Number |
25860351
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Chiba University |
Principal Investigator |
ONODERA Atsushi 千葉大学, 医学(系)研究科(研究院), 助教 (10586598)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 免疫記憶 / 発生・分化 / エピジェネティクス / アレルギー・ぜんそく / 発現制御 |
Outline of Final Research Achievements |
One-thirds of Japanese suffer from allergies, which are caused by imbalances in the immune system. We focus on helper T (Th) cells because they are thought to play important roles both in development of the allergic diseases and host defense against pathogens. Polycomb and Trithorax proteins regulate Th cell function via binding to specific genes, and we propose that their spatial interplay is crucial for regulating target gene transcription. In this study, we investigated the roles of Ezh2, one of the Polycomb group proteins, and demonstrated that it functions to prevent unwanted immune responses. We also clarified the roles of Menin, one of the Trithorax group proteins, in the pathogenesis of steroid-resistant asthma. We hope that these findings will be applied to the development of therapies for allergic disease.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.2014
Author(s)
Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, DJ., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 111(35)
Issue: 35
Pages: 12829-34
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR gamma t induction as downstream targets of Stat32014
Author(s)
Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H
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Journal Title
J Exp Med
Volume: 211
Issue: 9
Pages: 1857-1874
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.2014
Author(s)
Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A.
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Journal Title
Nature Communications
Volume: 18
Issue: 1
Pages: 5872-5882
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells.2013
Author(s)
Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.
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Journal Title
Immunity
Volume: 39
Issue: 5
Pages: 819-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Genomic-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity.2013
Author(s)
Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., Tanaka, H., Ogawa, Y., Suzuki, Y., and Nakayama, T.
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Journal Title
PLOS ONE
Volume: 8
Issue: 6
Pages: e66468-e66468
DOI
Related Report
Peer Reviewed
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[Presentation] Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORgt induction as downstream targets of Stat3.2014
Author(s)
Tanaka, S., Suto, A., Iwamoto, T., Suzuki, K., Takatori, H., Tamachi, T., Hirose, K., Onodera, A., Suzuki, J., Ohara, O., Yamashita, M., Nakayama, T., and Nakajima, H.
Organizer
第43回日本免疫学会総会・学術集会
Place of Presentation
国立京都国際会館、京都府、京都市
Year and Date
2014-12-10 – 2014-12-12
Related Report
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[Presentation] The trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.2014
Author(s)
Watanabe, Y., Onodera, A., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Morimoto, Y., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.
Organizer
第43回日本免疫学会総会・学術集会
Place of Presentation
国立京都国際会館、京都府、京都市
Year and Date
2014-12-10 – 2014-12-12
Related Report
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[Presentation] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells.2014
Author(s)
Tumes, J. D., Onodera, A., Hosokawa, H., Koseki, H., Suzuki, Y., Motohashi, S., and Nakayama, T.
Organizer
第24回Kyoto T cell Conference
Place of Presentation
京都平安ホテル、京都府、京都市
Year and Date
2014-05-16 – 2014-05-17
Related Report
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[Presentation] Cellular memory of T helper type 2 cells controlled by GATA3 and epigenetic regulators.
Author(s)
Onodera, A., Horiuchi, S., Sasaki, T., Hosokawa, H., Watanabe, Y., and Nakayama, T.
Organizer
第42回日本免疫学会総会学術集会
Place of Presentation
幕張メッセ (千葉県千葉市)
Related Report
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[Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells.
Author(s)
Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
Organizer
AAI Annual Meeting
Place of Presentation
Hawaii Convention Center (Honolulu, Hawaii)
Related Report
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