Is anti-HIV immunity from Asia consistent with the ones from Africa, Europe, and America?

• Project/Area Number: 25860367
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Nagasaki University
• Principal Investigator: MORI Masahiko 長崎大学, 熱帯医学研究所, 客員研究員 (50643988)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: HIV / HLA / KIR / タイ / 南アフリカ / アジア / Asia / （国際情報交換）Thailand / （国際研究者交流）UK / 東南アジア / 国際情報交換 / イギリス

Outline of Final Research Achievements

HLA: Human Leukocyte Antigen, which is a blood type of white blood cells, plays an important role in HIV viral control. Through our Thai cohort study, ①Contribution of HLA-B*57 alleles for viral control across ethnics and viral subtypes, ②HLA-B*35:05, which is unique allele among south-east population, was also detected as protective allele, ③however HLA-B*58:01 was not protective, inconsistent with African and Caucasian population, and ④Natural killer cell receptor KIR: Killer Immunoglobulin-like Receptor, which is a receptor of HLA-viral peptide complex, also effected on clinical outcome, with susceptible effect of KIR2DL3 on clinical outcomes,　were identified.

Research Products

• [Int'l Joint Research] National Institute of Health/Lampang hospital(Thailand)
• [Int'l Joint Research] University of Oxford(United Kingdom)
• [Int'l Joint Research] University of KwaZulu-Natal(South Africa)
• [Journal Article] The effect of KIR2D-HLA-C receptor-ligand interactions on clinical outcome in a HIV-1 CRF01_AE-infected Thai population. (2015)
  • Author(s): Masahiko Mori, Nuanjun Wichukchinda, Reiko Miyahara, Archawin Rojanawiwat, Panita Pathipvanich, Naho Tsuchiya, Toshiyuki Miura, Michio Yasunami, Koya Ariyoshi, and Pathom Sawanpanyalert
  • Journal Title: AIDS Volume: 29 Issue: 13 Pages: 1607-1615
  • DOI: 10.1097/qad.0000000000000747
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection (2015)
  • Author(s): Masahiko Mori, Emily Adland, Paolo Paioni, Alice Swordy, Luisa Mori, Leana Laker, Maximilian Muenchhoff, Philippa C. Matthews, Gareth Tudor-Williams, Nora Lavandier, Anriette van Zyl, Jacob Hurst, Bruce D. Walker, Thumbi Ndung’u, Andrew Prendergast, Philip Goulder, Pieter Jooste
  • Journal Title: PLoS ONE Volume: 10 Issue: 7 Pages: e0131591-e0131591
  • DOI: 10.1371/journal.pone.0131591
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HLA-B*35: 05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low (2014)
  • Author(s): Mori, Masahiko; Wichukchinda, Nuanjun; Miyahara, Reiko; Rojanawiwat, Archawin; Pathipvanich, Panita; Maekawa, Tomoyuki; Miura, Toshiyuki; Goulder, Philip; Yasunami, Michio; Ariyoshi, Koya; Sawanpanyalert, Pathom
  • Journal Title: AIDS Volume: 28 Pages: 959-967
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] HLA-B*35: 05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low. (2014)
  • Author(s): Masahiko Mori, Nuanjun Wichukchinda, Reiko Miyahara, Archawin Rojanawiwat, Panita Pathipvanich, Tomoyuki Maekawa, Toshiyuki Miura, Philip Goulder, Michio Yasunami, Koya Ariyoshi and Pathom Sawanpanyalert
  • Journal Title: AIDS Volume: 28 (7) Pages: 959-967
  • Peer Reviewed
• [Presentation] Deleterious Effect of KIR-HLA-associated Gag Sites on Clinical Outcome in CRF01_AE. (2016)
  • Author(s): Masahiko Mori, Nuanjun Wichukchinda, Reiko Miyahara, Archawin Rojanawiwat, Panita Pathipvanich, Toshiyuki Miura, Michio Yasunami, Koya Ariyoshi, and Pathom Sawanpanyalert.
  • Organizer: CROI: Conference on Retroviruses and opportunistic Infections
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] The effect of KIR-mediated immunity on HIV clinical outcome in South Africa. (2016)
  • Author(s): Masahiko Mori, Ellen Leitman, Bruce Walker, Thumbi Ndung’u, Philip Goulder
  • Organizer: CROI: Conference on Retroviruses and opportunistic Infections
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] Effect of KIR2D-mediated immunity on clinical outcome among CRF01_AE-infected Thais. (2015)
  • Author(s): Masahiko Mori, Nuanjun Wichukchinda, Reiko Miyahara, Archawin Rojanawiwat, Panita Pathipvanich, Toshiyuki Miura, Michio Yasunami, Koya Ariyoshi, and Pathom Sawanpanyalert.
  • Organizer: CROI: Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Seattle, US
  • Year and Date: 2015-02-25
• [Presentation] HLA-KIR-associated sites in Gag and their effects on clinical outcome in Thailand. (2015)
  • Author(s): Masahiko Mori, Nuanjun Wichukchinda, Reiko Miyahara, Archawin Rojanawiwat, Panita Pathipvanich, Toshiyuki Miura, Michio Yasunami, Koya Ariyoshi, and Pathom Sawanpanyalert.
  • Organizer: CROI: Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Seattle, US
  • Year and Date: 2015-02-25
• [Presentation] HLA-B*35: 05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low. (2014)
  • Author(s): Masahiko Mori, Nuanjun Wichukchinda, Reiko Miyahara, Archawin Rojanawiwat, Panita Pathipvanich, Tomoyuki Maekawa, Philip Goulder, Michio Yasunami, Koya Ariyoshi and Pathom Sawanpanyalert
  • Organizer: CROI: Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Boston, MA, USA