Molecular target treatment based on the pathological analysis of leukemia stem cells under mimicking bone marrow microenviroment in hypoxia
| Project/Area Number |
25860404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ITOH Mai 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (70415545)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 急性白血病 / 白血病幹細胞 / 低酸素培養 / 骨髄ニッチ / 白血病 / 低酸素 |
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| Outline of Final Research Achievements |
For treatment of acute leukemia, it is necessary to eradicate leukemia stem cells which reside in bone marrow microenviroment in hypoxia. We found that HIF protein expression was upregulated, in association with downregulating of Notch, mTOR, or NF-κB signals when leukemia cell lines were cultured in hypoxia. Activated Notch signal was also downregulated in hypoxia. The reactivity in hypoxia was different between normal blood cells and leukamia cell lines with respect to the expression of HIF protein.
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Report
(4 results)
Research Products
(22 results)
