| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
For treatment of acute leukemia, it is necessary to eradicate leukemia stem cells which reside in bone marrow microenviroment in hypoxia. We found that HIF protein expression was upregulated, in association with downregulating of Notch, mTOR, or NF-κB signals when leukemia cell lines were cultured in hypoxia. Activated Notch signal was also downregulated in hypoxia. The reactivity in hypoxia was different between normal blood cells and leukamia cell lines with respect to the expression of HIF protein.
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