| Project/Area Number |
25860408
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YAMAGUCHI Natsu 山口大学, 医学(系)研究科(研究院), 助教 (40450671)
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| Research Collaborator |
TANABE Tsuyoshi 山口大学, 大学院医学系研究科, 教授 (80260678)
TAKAHASHI Hidekazu 山口大学, 大学院医学系研究科, 講師 (90450402)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨髄移植 / 遺伝子多型 / 炎症関連因子 / NLRP / インフラマソーム / 移植片対宿主病 / GVHD / 多変量解析 / 遺伝子多型解析 / 骨髄移植後合併症 / SNP |
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| Outline of Final Research Achievements |
The NLRP inflammasomes are key regulators of innate immunity. We investigated the relationship between the single nucleotide polymorphisms (SNPs) of human NLRP1-3 genes and the prognosis of unrelated bone marrow transplantation. As a result, the interactions between the donor-recipient HLA mismatches and a recipient NLRP3 SNP were associated with grade 2-4 acute graft versus host disease (GVHD) with statistical significance. Moreover, the interaction between the donor-recipient HLA-C mismatch and a donor NLRP3 SNP were statistically significantly associated with extensive chronic GVHD. We also found that the interaction between donor cytomegalovirus serostatus and recipient NLRP3 SNP were statistically significantly associated with overall survival. These results should be validated in larger populations.
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