A prospective cohort study of the interactive effects of vitamin D and calcium for diabetes prevention.

• Project/Area Number: 25860443
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Juntendo University (2014-2015); Ehime University (2013)
• Principal Investigator: Maruyama Koutatsu 順天堂大学, 医学(系)研究科(研究院), 助教 (20627096)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ビタミンD / カルシウム / 耐糖能異常 / 糖尿病 / コホート研究 / インスリン抵抗性 / 飲酒 / 横断研究

Outline of Final Research Achievements

The objective of this study was to examine the lifestyles associated with vitamin D intake and also to examine the preventive effects of vitamin D as well as calcium intake on incidence of glucose abnormality. Our present cross-sectional study showed that persons with higher vitamin D intake were older and had higher mean intakes of vegetables and fishes. We also found that women with higher vitamin D intake were likely to have better results on makers of insulin resistance and those with higher dairy product intakes were likely to have lower levels of systolic and diastolic blood pressure. These results were more evident among women with small amount of alcohol drink (<1 go/day). Furthermore, the results from our prospective 5-year followed-up study showed that higher vitamin D intake at baseline was associated with reduced incidence of high blood glucose among persons who had higher intake of calcium.

Research Products

• [Journal Article] The impact of masticatory ability as evaluated by salivary flow rates on obesity in Japanese: The Toon health study (2015)
  • Author(s): Maruyama K, Nishioka S, Miyoshi N, Higuchi K, Mori H, Tanno S, Tomooka K, Eguchi E, Furukawa S, Saito I, Sakurai S, Nishida W, Osawa H, Tanigawa T.
  • Journal Title: Obesity Volume: 23 Issue: 6 Pages: 1296-302
  • DOI: 10.1002/oby.21071
  • Peer Reviewed
• [Presentation] カルシウム・乳製品と血圧との関係におけるビタミンD摂取の相互作用について：東温スタディ (2014)
  • Author(s): 丸山広達
  • Organizer: 第1回 日本栄養改善学会四国支部学術総会
  • Place of Presentation: 徳島
  • Year and Date: 2014-05-17
• [Presentation] ビタミンD摂取とインスリン抵抗性・感受性との関連：東温スタディ
  • Author(s): 丸山広達
  • Organizer: 第60回日本栄養改善学会学術総会
  • Place of Presentation: 神戸国際会議場