Strong Association between Plasma Aldosterone and the Metabolic Syndrome

• Project/Area Number: 25860453
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kurume University
• Principal Investigator: Nohara Yume 久留米大学, 医学部, 助教 (10647811)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 疫学 / メタボリック症候群 / アルドステロン

Outline of Final Research Achievements

A total of 1,235 participants (490 men, 745 women) underwent health check-ups in 1999. We measured components of metabolic syndrome (blood pressure, waist circumference, fasting plasma glucose, and lipid profiles). At the 10-year follow-up, we performed a prospective analysis of 564 subjects to predict incident metabolic syndrome. However, no significant associations were found between plasma aldosterone levels and components of metabolic syndrome. In the prospective analysis, a significantly higher relative risk (1.71 [95% CI: 1.03-2.84]) was observed in the highest tertile versus lowest tertile of plasma aldosterone for the development of insulin resistance, after adjustment for confounding factors. This 10-year prospective study demonstrated that plasma aldosterone levels predicted the development of insulin resistance in a general population.