Measurement of gastrointestinal pH profiles by pH capsule

• Project/Area Number: 25860506
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yokohama City University
• Principal Investigator: IIDA HIROSHI 横浜市立大学, 医学部, 助教 (80600204)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 小腸 / pH / 消化管

Outline of Final Research Achievements

We invented the novel device named “pH capsule” which noninvasively record both sequential images and pH within the gastrointestinal tract （Iida H, et al. A new non-invasive modality for recording sequential images and the pH of the small bowel. Hepatogastroenterology 2011;59:114）. The aim of this study was to investigate the pH changes from the terminal ileum to cecum by using the “pH capsule”.
Evans D F reported the measurement of gastrointestinal pH profiles in normal ambulant human subjects by using pH sensitive radiometry capsule in 1988 （Evans D F et al. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 1988;29:1035-41）.
We confirmed by using "pH capsule" that the pH in the normal gastrointestinal increase in pH from the duodenum to the terminal ileum, decrease in the cecum.

Research Products

• [Journal Article] Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH. (2015)
  • Author(s): Iida H, Inamori M, Okuno K, Sekino Y, Sakai E, Okubo H, Higurashi T, Endo H, Hosono K, Yoneda M, Koide T, Takahashi H, Goto A, Kubota K, Saito S, Maeda S, Nakajima A, Gotoh E.
  • Journal Title: Hepatogastroenterology Volume: 138 Pages: 493-6
  • Peer Reviewed / Open Access
• [Journal Article] Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System). (2015)
  • Author(s): Inoue S, Sakamoto Y, Sekino Y, Nonaka T, Iida H, Endo H, Koide T, Takahashi H,Maeda S, Nakajima A, Gotoh E, Inamori M.
  • Journal Title: Turk J Gastroenterol. Volume: 26 Issue: 2 Pages: 123-7
  • DOI: 10.5152/tjg.2015.4768
  • Peer Reviewed
• [Journal Article] よく使う日常治療薬の正しい使い方 慢性便秘の治療薬の使い方 (2015)
  • Author(s): 中島 淳, 稲生 優海, 冬木 晶子, 大久保 秀則, 飯田 洋, 稲森 正彦
  • Journal Title: レジデントノート Volume: 16 Pages: 2873-8
• [Journal Article] Ischemic gastritis. (2014)
  • Author(s): Oshima A, Hosono K, Ito S, Sekino Y, Iida H, Nonaka T, Yamanaka S, Nakajima A, Maeda S, Gotoh E, Inamori M.
  • Journal Title: Turk J Gastroenterol Volume: 25 Issue: 1 Pages: 289-290
  • DOI: 10.5152/tjg.2014.4114
  • Peer Reviewed
• [Journal Article] A metastatic melanoma of the small intestine diagnosed by single-balloon enteroscopy. (2014)
  • Author(s): Suzuki K, Akimoto K, Fujisawa N, Koyama S, Tsunemi A, Tanaka M, Sekino Y, Iida H, Nonaka T, Nakajima A, Maeda S, Gotoh E, Inamori M.
  • Journal Title: Turk J Gastroenterol Volume: 25 Issue: 1 Pages: 262-263
  • DOI: 10.5152/tjg.2014.4113
  • Peer Reviewed
• [Journal Article] Percutaneus endoscopic gastrostomy in a patient with hemophilia A. (2014)
  • Author(s): Koide T, Iinuma M, Sakai E, Yamada E, Higurashi T, Ohkubo H, Iida H, Hosono K, Endo H, Nonaka T, Fujita K, Takahashi H, Yoneda M, Goto A, Ida T, Kusakabe A, Nakajima A, Maeda S, Gotoh E, Inamori M.
  • Journal Title: Turk J Gastroenterol Volume: 25 Issue: 1 Pages: 241-241
  • DOI: 10.5152/tjg.2014.5262
  • Peer Reviewed
• [Journal Article] Correlation between gastric transit time measured by video capsule endoscopy and gastric emptying determined by the continuous real-time 13C breath test (BreathID system). (2014)
  • Author(s): Nonaka T, Inamori M, Endo H, Matsuura M, Uchiyama S, Yamada E, Sekino Y, Sakai E, Higurashi T, Ohkubo H, Akimoto K, Iida H, Takahashi H, Koide T, Shibata W, Ida T, Kusakabe A, Gotoh E, Nakajima A, Maeda S.
  • Journal Title: Hepatogastroenterology Volume: 135 Pages: 2159-62
  • Peer Reviewed / Open Access
• [Journal Article] Effects of ramosetron oral disintegrating tablets on gastric emptying: crossover study using the 13C-acetic acid breath test. (2014)
  • Author(s): Kusakabe A, Nonaka T, Sekino Y, Iida H, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Gotoh E, Maeda S, Nakajima A, Nosaka C, Inamori M.
  • Journal Title: Hepatogastroenterology Volume: 133 Pages: 1279-82
  • Peer Reviewed / Open Access
• [Journal Article] Comparative study of the QUEST questionnaire and GerdQ questionnaire for Japanese students. (2014)
  • Author(s): Kikkawa N, Inamori M, Inoue S, Mori Y, Iida H, Nonaka T, Kusakabe A, Nakajimaz A, Maeda S, Gotoh E.
  • Journal Title: Hepatogastroenterology Volume: 134 Pages: 1605-10
  • Peer Reviewed / Open Access
• [Journal Article] Postpyloric decompression tube placement through a gastrostomy for malignant bowel obstruction (2013)
  • Author(s): Kurita Y, Koide T, Watanabe S, Ogawa T, Sekino Y, Iida H, Nonaka T, Kusakabe A, Gotoh E, Maeda S, Nakajima A, Inamori M
  • Journal Title: BMC Res Notes Volume: 6 Issue: 1 Pages: 217-217
  • DOI: 10.1186/1756-0500-6-217
  • Peer Reviewed
• [Journal Article] Inamori MEarly Effect of Single-dose Sitagliptin Administration on Gastric Emptying : Crossover Study Using the (13)C Breath Test (2013)
  • Author(s): Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Hosono K, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Kusakabe A, Kobayashi N, Gotoh E, Maeda S, Nakajima A, Nosaka C
  • Journal Title: J Neurogastroenterol Motil. Volume: 19 Issue: 2 Pages: 227-32
  • DOI: 10.5056/jnm.2013.19.2.227
  • Peer Reviewed
• [Journal Article] Characteristics of the small bowel lesions detected by capsule endoscopy in patients with chronic kidney disease. (2013)
  • Author(s): Kawamura H, Sakai E, Endo H, Taniguchi L, Hata Y, Ezuka A, Nagase H, Kessoku T, Yamada E, Ohkubo H, Higrashi T, Sekino Y, Koide T, Iida H, Nonaka T, Takahashi H, Inamori M, Maeda S, Nakajima A.
  • Journal Title: Gastroenterol Res Pract Volume: 81 Pages: 42-42
  • DOI: 10.1155/2013/814214
  • Peer Reviewed
• [Journal Article] Case report; a case of congenital haptoglobin deficiency diagnosed after transfusion for esophageal varix rupture (2013)
  • Author(s): Azuma A, Iida H, Yoneda M, Takahashi H, Inamori M, Kirikoshi H, Nakajima A, Maeda S, Saito S, Kamijyo A
  • Journal Title: Nihon Naika Gakkai Zasshi Volume: 102 Pages: 2980-2
  • NAID: 40019871188
  • Peer Reviewed
• [Journal Article] Epidemiology and clinical experience of chronic intestinal pseudo-obstruction in Japan: a nationwide epidemiologic survey. (2013)
  • Author(s): Iida H, Ohkubo H, Inamori M, Nakajima A, Sato H.
  • Journal Title: J Epidemiol Volume: 23 Pages: 288-94
  • NAID: 10031183195
  • Peer Reviewed
• [Journal Article] Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI. (2013)
  • Author(s): Ohkubo H, Kessoku T, Fuyuki A, Iida H, Inamori M, Fujii T, Kawamura H, Hata Y, Nakajima A, Tkahara T
  • Journal Title: Am J Gastroenterol Volume: １０８ Issue: 7 Pages: 1130-9
  • DOI: 10.1038/ajg.2013.57
  • Peer Reviewed
• [Journal Article] Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding. (2013)
  • Author(s): Sakai E, Endo H, Taniguchi L, Hata Y, Ezuka A, Nagase H, Yamada E, Ohkubo H, Higurashi T, Sekino Y, Koide T, Iida H, Hosono K, Nonaka T, Takahashi H, Inamori M, Maeda S, Nakajima A.
  • Journal Title: Dig Endosc. Volume: 25 Issue: 4 Pages: 412-420
  • DOI: 10.1111/den.12002
  • Peer Reviewed
• [Journal Article] 逆流性食道炎患者におけるエソメプラゾール投与後の満足度の検討 PPI切り替え後の自己記入式問診における患者満足度の検討 (2013)
  • Author(s): 吉川 奈緒美, 稲森 正彦, 松浦 端恵, 内山 詩織, 山田 英司, 日暮 琢磨, 大久保 秀則, 酒井 英嗣, 飯田 洋, 遠藤 宏樹, 野中 敬, 高橋 宏和, 古出 智子, 芝田 渉, 井田 智則, 日下部 明彦, 後藤 英司, 中島 淳, 前田 愼
  • Journal Title: 消化器の臨床 Volume: 16 Pages: 321-8
  • Peer Reviewed
• [Journal Article] 動脈硬化・糖尿病などの生活習慣病とHelicobacter pyloriの関連 (2013)
  • Author(s): 飯田 洋, 稲森 正彦, 中島 淳
  • Journal Title: Helicobacter Research Volume: 17 Pages: 312-5
• [Presentation] EsomeprazokeとOmeprazoleの単回経口投与における胃内pHの立ち上がりに関する検討 (2014)
  • Author(s): 飯田洋，山田英司，大久保秀則，日暮琢磨，酒井英嗣，細野邦広，遠藤宏樹，野中敬，古出智子，高橋宏和，米田正人，後藤歩，桐越博之，窪田賢輔，斉藤聡，後藤英司，前田愼，中島淳，稲森正彦
  • Organizer: 日本消化器関連学会週間（JDDW 2014）
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] THE PH IN THE NORMAL GASTROINTESTINAL DECREASE FROM THE TERMINAL ILEUM TO CECUM BY USING “PH CAPSULE” FOR RECORDING SEQUENTIAL IMAGES AND THE PH OF THE GASTROINTESTINAL TRACT (2014)
  • Author(s): H Iida
  • Organizer: UEGW2014
  • Place of Presentation: Austria, Vienna
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] 胸焼け患者に対するRoxatidine単回内服投与の効果に関する検討 (2014)
  • Author(s): 飯田洋，山田英司，大久保秀則，日暮琢磨，酒井英嗣，細野邦広，遠藤宏樹，野中敬，古出智子，高橋宏和，米田正人，後藤歩，桐越博之，窪田賢輔，斉藤聡，後藤英司，前田愼，中島淳，稲森正彦
  • Organizer: 第87回日本消化器内視鏡学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] Rabeprazoleの胃内pHの立ち上がりに関するmosaprideの効果についての検討 (2014)
  • Author(s): 飯田洋，石井研，松浦瑞恵，内山詩織，山田英司，酒井英嗣，大久保秀則，日暮琢磨，遠藤宏樹，野中敬，古出智子，高橋宏和，後藤歩，桐越博之，窪田賢輔，斎藤聡，後藤英司，稲森正彦，中島淳，前田愼
  • Organizer: 第10回日本消化管学会総会学術集会
  • Place of Presentation: 福島ビューホテル（福島県福島市）
• [Presentation] EsomeprazokeとOmeprazoleの単回経口投与における胃内pHの立ち上がりに関する検討 (2013)
  • Author(s): 飯田洋，山田英司，大久保秀則，日暮琢磨，酒井英嗣，細野邦広，遠藤宏樹，野中敬，古出智子，高橋宏和，米田正人，後藤歩，桐越博之，窪田賢輔，斉藤聡，後藤英司，前田愼，中島淳，稲森正彦
  • Organizer: 日本消化器関連学会週間（JDDW 2013）
  • Place of Presentation: 品川プリンス（東京都港区）
• [Presentation] GERDに対する消化管運動機能改善薬の可能性～酸分泌抑制薬の胃内pH立ち上がりに関するクエン酸モサプリド併用効果についての検討～ (2013)
  • Author(s): 飯田洋
  • Organizer: 第15回日本神経消化器病学会
  • Place of Presentation: ビッグハート出雲（島根県出雲市）
  • Invited
• [Presentation] Rabeprazoleの胃内pHの立ち上がりに関するmosaprideの効果についての検討 (2013)
  • Author(s): 飯田洋，石井研，松浦瑞恵，内山詩織，山田英司，酒井英嗣，大久保秀則，日暮琢磨，遠藤宏樹，野中敬，古出智子，高橋宏和，後藤歩，桐越博之，窪田賢輔，斎藤聡，後藤英司，稲森正彦，中島淳，前田愼
  • Organizer: 第15回日本神経消化器病学会
  • Place of Presentation: ビッグハート出雲（島根県出雲市）
• [Book] 意外と知らない くすりのTips (2015)
  • Author(s): 稲森正彦、飯田洋、井上祥、田部井正
  • Total Pages: 301
  • Publisher: メジカルレビュー社
• [Remarks] 横浜市立大学医学部肝胆膵消化器病学
  • URL: http://ycuhepabiligi.wix.com/home
• [Remarks] 横浜市立大学機能消化管グループ
  • URL: https://www.facebook.com/yokohamakinoushokakann?fref=nf
• [Remarks] 横浜市立大学大学院医学研究科 分子消化管内科
  • URL: http://www-user.yokohama-cu.ac.jp/~nai3syou/index.html
• [Remarks] 横浜市立大学医学部消化器内科 機能消化管グループ
  • URL: http://www014.upp.so-net.ne.jp/inamorim/