Diagnosing pancreatic diseases and predicting therapeutic efficacy by using next generation sequencing
| Project/Area Number |
25860527
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膵腫瘍 / 次世代シークエンサー / 遺伝子変異 / 膵液 / 膵管内乳頭粘液性腫瘍 / 膵癌 / GNAS変異 / IPMN |
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| Outline of Final Research Achievements |
Pancreatic neoplasms such as pancreatic cancer and intraductal papillary mucinous neoplasms are still difficult to diagnose and treat because of insufficient availability of obtaining specimens preoperatively. On the other hand, rapid progress of technical improvements has enabled us to examine genetic abnormalities with a small amount of clinical samples easily.
In this study, we analysed mutational status of pancreatic diseases using clinically obtained pancreatic juice and found that GNAS mutation seen in cases with IPMN is associated with dilation of main pancreatic duct. Though the meanings of this findings need more analysis, we believe our study will contributes to clarify causes of pancreatic disease.
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Report
(3 results)
Research Products
(9 results)
