| Project/Area Number |
25860533
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
KANDA Keitaro 京都大学, 医学(系)研究科(研究院), 医員 (30609061)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / 大腸 / NRDc / TNF-α / TACE |
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| Outline of Final Research Achievements |
Frequency of colorectal cancer is increasing in Jaapn, and it is important to find novel therapeutic strategies. For that purpose, we focused on the role of NRDc during colorectal tumorigenesis. In NRDc knockout mice, intestinal tumorigenesis caused by AOM/DSS or insertion of Apc gene mutation was significantly suppressed concomitantly with decreased TACE activity, TNF-alpha shedding, and NF-kappaB activation. In colorectal cancer patients, serum NRDc level was elevated compared to healthy controls, and inhibition of NRDc significantly suppressed the growth of human colorectal cancer cell lines and xenografts. Thus, this study suggest us the potential of NRDc as a therapeutic target against colorectal cancer.
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