Development of the method for predicting sensitivity to chemoradiothrapy for esophageal cancer using comprehensive gene expression profiling analysis
Project/Area Number |
25860546
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
|
Research Institution | Sapporo Medical University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 食道癌 / 化学放射線療法 / 感受性予測 / miRNA / 効果予測因子 |
Outline of Final Research Achievements |
We performed comprehensive miRNA expression profiling analysis in pretherapeutic biopsies of responders and nonresponders in chemoradiotherapy using docectacel, nedaplatin and 5-FU of esophageal cancer, and the miRNA profiling revealed the expression of hsa-miR-625-3p and hsa-miR-4731-3p was significantly higher in the responder group. As validation analysis, we are examining the mechanism for acquiring CRT resistance using esophageal cancer cell lines transfected with the candidate miRNAs.
|
Report
(3 results)
Research Products
(3 results)
-
-
[Presentation] A phase I/II study of definitive chemoradiotherapy with docetaxel, nedaplatin, and 5-fluorouracil (DNF-R) for advanced esophageal cancer.2015
Author(s)
Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Masakazu Hori, Masanori Someya, Koh-ichi Sakata, Tetsuji Takayama, Junji Kato
Organizer
2015 Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology
Place of Presentation
Moscone West Building (San Francisco, CA)
Year and Date
2015-01-15 – 2015-01-17
Related Report
-