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Massively-Parallel Sequencing reveals molecular mechanism of gastric carcinogenesis after helicobactor pylori eradication

Research Project

Project/Area Number 25860548
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

SUZUKI Ryo  札幌医科大学, 医学部, 研究員 (60646587)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胃がん / メチル化 / バイオマーカー / ピロリ菌
Outline of Final Research Achievements

We performed prospective cohort study designed to assess the utility of DNA methylation as a predictive marker of metachronous GC risk.We found that methylation of miR-34b/c, SFRP2 and DKK2 in the gastric body mucosa was strongly associated with a risk for metachronous GC, and miR-34b/c showed the greatest potential to serve as a predictive marker.Furthermore, we found that miR-34b/c methylation was also associated with metachronous GC risk in patients who underwent successful H. pylori eradication after treatment of their GC.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013

    • Author(s)
      Suzuki R, Nosho K (他14名), Yamamoto H, Shinomura Y
    • Journal Title

      J Gastroenterol

      Volume: (Epub ahead of print) Issue: 7 Pages: 1135-1144

    • DOI

      10.1007/s00535-013-0861-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.2013

    • Author(s)
      Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
    • Journal Title

      J Gastroenterol.

      Volume: Equb ahead of print Pages: 9999-9999

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予想

    • Author(s)
      鈴木亮
    • Organizer
      内科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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