Massively-Parallel Sequencing reveals molecular mechanism of gastric carcinogenesis after helicobactor pylori eradication
| Project/Area Number |
25860548
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SUZUKI Ryo 札幌医科大学, 医学部, 研究員 (60646587)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胃がん / メチル化 / バイオマーカー / ピロリ菌 |
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| Outline of Final Research Achievements |
We performed prospective cohort study designed to assess the utility of DNA methylation as a predictive marker of metachronous GC risk.We found that methylation of miR-34b/c, SFRP2 and DKK2 in the gastric body mucosa was strongly associated with a risk for metachronous GC, and miR-34b/c showed the greatest potential to serve as a predictive marker.Furthermore, we found that miR-34b/c methylation was also associated with metachronous GC risk in patients who underwent successful H. pylori eradication after treatment of their GC.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.2013
Author(s)
Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
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Journal Title
J Gastroenterol.
Volume: Equb ahead of print
Pages: 9999-9999
Related Report
Peer Reviewed
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