| Project/Area Number |
25860576
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Department of Clinical Research, National Hospital Organization Nagasaki Medical Center |
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Principal Investigator |
AIBA YOSHIHIRO 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 研究員 (70450955)
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 原発性胆汁性肝硬変 / 疾患感受性遺伝子 / 肝臓 |
|---|
| Outline of Final Research Achievements |
Systemic and local levels of TL1A, a newly identified disease-susceptibility gene for PBC in a Japanese population, were increased in PBC patients. In response to UDCA treatment, serum TL1A levels were significantly decreased in early-stage PBC patients. On the other hand, they remained higher in late-stage PBC patients even after UDCA treatment. These results potentially indicate that TL1A might be a new therapeutic target for PBC, especially for the late-stage patients. In addition, in vivo and in vitro analyses indicate that TL1A signaling may be involved in PBC pathogenesis via infiltrating T lymphocytes rather than direct injury of intrahepatic bile ducts.
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