Role of new disease-susceptibility gene in the development and pathogenesis of PBC
Project/Area Number |
25860576
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Department of Clinical Research, National Hospital Organization Nagasaki Medical Center |
Principal Investigator |
AIBA YOSHIHIRO 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 研究員 (70450955)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 原発性胆汁性肝硬変 / 疾患感受性遺伝子 / 肝臓 |
Outline of Final Research Achievements |
Systemic and local levels of TL1A, a newly identified disease-susceptibility gene for PBC in a Japanese population, were increased in PBC patients. In response to UDCA treatment, serum TL1A levels were significantly decreased in early-stage PBC patients. On the other hand, they remained higher in late-stage PBC patients even after UDCA treatment. These results potentially indicate that TL1A might be a new therapeutic target for PBC, especially for the late-stage patients. In addition, in vivo and in vitro analyses indicate that TL1A signaling may be involved in PBC pathogenesis via infiltrating T lymphocytes rather than direct injury of intrahepatic bile ducts.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population2015
Author(s)
Yoshihiro Aiba, Keiko Yamazaki, Nao Nishida, Minae Kawashima, Yuki Hitomi, Hitomi Nakamura, Atsumasa Komori, Yuta Fuyuno, Atsushi Takahashi, Takaaki Kawaguchi, Masakazu Takazoe, Yasuo Suzuki, Satoshi Motoya Toshiyuki Matsui Motohiro Esaki, Takayuki Matsumoto, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
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Journal Title
Journal of Human Genetics
Volume: 印刷中
Issue: 9
Pages: 525-531
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis.2013
Author(s)
Aiba Y, Harada K, Komori A, Ito M, Shimoda S, Nakamura H, Nagaoka S, Abiru S, Migita K, Ishibashi H, Nakanuma Y, Nishida N, Kawashima M, Tokunaga K, Yatsuhashi H, Nakamura M.
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Journal Title
Liver Int.
Volume: 34
Issue: 5
Pages: 679-688
DOI
Related Report
Peer Reviewed
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[Presentation] Systemic and local expression of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis
Author(s)
Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda, Shinya Nagaoka, Seigo Abiru, Kiyoshi Migita, Hiromi Ishibashi, Yasuni Nakanuma, Nao Nishida, Minae Kawashima, Katsushi Tokunaga, Hiroshi Yatsuhashi, Minoru Nakamura
Organizer
The American Association for the Study of Liver Diseases (AASLD) the Liver Meeting Washington
Place of Presentation
Washington Convention Center
Related Report