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Role of new disease-susceptibility gene in the development and pathogenesis of PBC

Research Project

Project/Area Number 25860576
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionDepartment of Clinical Research, National Hospital Organization Nagasaki Medical Center

Principal Investigator

AIBA YOSHIHIRO  独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 研究員 (70450955)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords原発性胆汁性肝硬変 / 疾患感受性遺伝子 / 肝臓
Outline of Final Research Achievements

Systemic and local levels of TL1A, a newly identified disease-susceptibility gene for PBC in a Japanese population, were increased in PBC patients. In response to UDCA treatment, serum TL1A levels were significantly decreased in early-stage PBC patients. On the other hand, they remained higher in late-stage PBC patients even after UDCA treatment. These results potentially indicate that TL1A might be a new therapeutic target for PBC, especially for the late-stage patients. In addition, in vivo and in vitro analyses indicate that TL1A signaling may be involved in PBC pathogenesis via infiltrating T lymphocytes rather than direct injury of intrahepatic bile ducts.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population2015

    • Author(s)
      Yoshihiro Aiba, Keiko Yamazaki, Nao Nishida, Minae Kawashima, Yuki Hitomi, Hitomi Nakamura, Atsumasa Komori, Yuta Fuyuno, Atsushi Takahashi, Takaaki Kawaguchi, Masakazu Takazoe, Yasuo Suzuki, Satoshi Motoya Toshiyuki Matsui Motohiro Esaki, Takayuki Matsumoto, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
    • Journal Title

      Journal of Human Genetics

      Volume: 印刷中 Issue: 9 Pages: 525-531

    • DOI

      10.1038/jhg.2015.59

    • NAID

      40020589506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Human primary biliary cirrhosis-susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1.2015

    • Author(s)
      Hitomi Y, Kawashima M, Aiba Y, Nishida N, Matsuhashi M, Okazaki H, Nakamura M, Tokunaga K
    • Journal Title

      Human Genetics

      Volume: 印刷中 Issue: 7 Pages: 737-747

    • DOI

      10.1007/s00439-015-1556-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis.2013

    • Author(s)
      Aiba Y, Harada K, Komori A, Ito M, Shimoda S, Nakamura H, Nagaoka S, Abiru S, Migita K, Ishibashi H, Nakanuma Y, Nishida N, Kawashima M, Tokunaga K, Yatsuhashi H, Nakamura M.
    • Journal Title

      Liver Int.

      Volume: 34 Issue: 5 Pages: 679-688

    • DOI

      10.1111/liv.12296

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of TL1A and DR3 in autoimmune and inflammatory diseases.2013

    • Author(s)
      Aiba Y , Nakamura M.
    • Journal Title

      Mediators of Inflammation

      Volume: 未 Pages: 258164-258164

    • DOI

      10.1155/2013/258164

    • NAID

      120006986697

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 日本人の原発性胆汁性肝硬変とクローン病における疾患感受性遺伝子の共通性と異質性2015

    • Author(s)
      相葉佳洋、山﨑慶子、川嶋実苗、西田奈央、小森敦正, 4, 久保充明、徳永勝士、中村稔
    • Organizer
      第59回日本人類遺伝学会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-11-19 – 2015-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] SHARED DISEASE-SUSCEPTIBILITY GENES BETWEEN PRIMARY BILIARY CIRRHOSIS AND CROHN’S DISEASE IN THE JAPANESE POPULATION2015

    • Author(s)
      Yoshihiro Aiba, Keiko Yamazaki, Nao Nishida, Minae Kawashima, Yuki Hitomi, Atsumasa Komori, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
    • Organizer
      The 50th International Liver Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-04-22 – 2015-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of primary biliary cirrhosis - susceptible variant in human TNFSF15 locus and its functional analysis2014

    • Author(s)
      Yuki Hitomi, Minae Kawashima, Yoshihiro Aiba, Nao Nishida, Minoru Nakamura, Katsushi Tokunaga
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府、京都市
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本人原発性胆汁性肝硬変とクローン病に共通する疾患感受性遺伝子の検討2014

    • Author(s)
      相葉佳洋、山﨑慶子、川嶋実苗、西田奈央、小森敦正, 久保充明、徳永勝士、中村稔
    • Organizer
      第51回日本消化器免疫学会
    • Place of Presentation
      京都大学医学部 芝蘭会館(京都府、京都市
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト胆管上皮細胞における TL1A 産生機構の解析2013

    • Author(s)
      相葉佳洋、小森敦正, 伊東正博, 右田清志, 八橋 弘, 中村 稔.
    • Organizer
      第41回日本臨床免疫学会総会
    • Place of Presentation
      海峡メッセ下関
    • Related Report
      2013 Research-status Report
  • [Presentation] 日本人原発性胆汁性肝硬変患者におけるTLIAの役割

    • Author(s)
      相葉佳洋、原田憲一, 小森敦正, 伊東正博, 阿比留正剛, 長岡進矢, 石橋大海, 中沼安二, 八橋 弘, 中村 稔.
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] 原発性胆汁性肝硬変の肝局所におけるTL1A産生機構の解明

    • Author(s)
      相葉佳洋、原田憲一, 小森敦正, 阿比留正剛, 長岡進矢, 右田清志, 伊東正博, 中沼安二, 八橋 弘, 中村 稔.
    • Organizer
      第50回日本消化器免疫学会総会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷
    • Related Report
      2013 Research-status Report
  • [Presentation] The mechanism of TL1A production in human biliary epithelial cells

    • Author(s)
      Yoshihiro Aiba, Komori A, Ito M, Migita K, Yatsuhashi H, Nakamura M.
    • Organizer
      Annual Meeting of The Japanese Society for Immunology, 2013
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Research-status Report
  • [Presentation] Systemic and local expression of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis

    • Author(s)
      Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda, Shinya Nagaoka, Seigo Abiru, Kiyoshi Migita, Hiromi Ishibashi, Yasuni Nakanuma, Nao Nishida, Minae Kawashima, Katsushi Tokunaga, Hiroshi Yatsuhashi, Minoru Nakamura
    • Organizer
      The American Association for the Study of Liver Diseases (AASLD) the Liver Meeting Washington
    • Place of Presentation
      Washington Convention Center
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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