Development of novel serum marker and treatment for interstitilal lung diseases
Project/Area Number |
25860649
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | Nagasaki University |
Principal Investigator |
KAKUGAWA Tomoyuki 長崎大学, 医歯薬学総合研究科(医学系), 助教 (90570953)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 特発性間質性肺炎 / 特発性肺線維症 / 急性増悪 / バイオマーカー / HSP47 / 急性間質性肺炎 / 薬剤性肺炎 / 急性呼吸窮迫症候群 / びまん性肺胞傷害 / 血清マーカー |
Outline of Final Research Achievements |
Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is essential for the biosynthesis and secretion of collagen molecules. Previous studies of various experimental diseases affecting the lung have shown that there is a close association between increased expression of HSP47 and excessive accumulation of collagen. In our study, serum HSP47 levels were significantly higher in patients with acute exacerbation of idiopathic pulmonary fibrosis, acute interstitial pneumonia, and drug induced lung disease with diffuse alveolar damage (DAD) pattern than those in patients with stable idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, cryptogenic organizing pneumonia, and healthy volunteers, suggesting that underlying fibrogenic mechanisms involving HSP47 differ in the two conditions. Elevation of serum HSP47 might be due to distinctive characteristics of DAD. DAD changes may possibly induce leakage of HSP47 protein into the extracellular matrix.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia.2014
Author(s)
Kakugawa, T., Yokota, S.I., Ishimatsu, Y., Hayashi, T., Nakashima, S., Hara, S., Sakamoto, N., Kubota, H., Mine, M., Matsuoka, Y., Mukae, H., Nagata, K., and Kohno, S.
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Journal Title
BMC Pulm. Med.
Volume: 14
Issue: 1
Pages: 48-48
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis2013
Author(s)
Kakugawa, T., Yokota, S.I., Ishimatsu, Y., Hayashi. T., Nakashima, S., Hara, S., Sakamoto, N., Kubota, H., Mine, M., Matsuoka, Y., Mukae, H., Nagata, K., and Kohno, S.
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Journal Title
Cell Stress Chaperones
Volume: 18
Issue: 5
Pages: 581-590
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum heat shock protein 47 levels in patients with drug-induced lung disease.2013
Author(s)
Kakugawa, T., Yokota, S., Ishimatsu, Y., Hayashi, T., Nakashima, S., Hara, S., Sakamoto, N., Kubota, H., Mine, M., Y., Matsuoka, Y., Mukae, H., Nagata, K., and Kohno, S.
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Journal Title
Respir. Res.
Volume: 14
Issue: 1
Pages: 133-133
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical, serologic and magnetic resonance imaging of 3 cases of inflammatory myopathy with abundant macrophages in the japanese population.2013
Author(s)
Hara S, Henmi T, Kawakami A, Fujikawa K, Mukae H, Ishimatsu Y, Sakamoto N, Kakugawa T, Kaji K, Fujimoto M, Kuwana M, Tsukada T, Satoh K, Motomura M, Tamai M, Nakamura H, Ida H, Hayashi T, Origuchi T, Eguchi K, Kohno S.
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Journal Title
Rheumatology International
Volume: 33
Pages: 1059-1064
NAID
Related Report
Peer Reviewed
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[Presentation] Serum heat shock protein 47 levels in patients with drug-induced lung disease2013
Author(s)
Tomoyuki Kakugawa, Shin-ichi Yokota, Yuji Ishimatsu, Tomayoshi Hayashi, Shota Nakashima, Shintaro Hara, Noriho Sakamoto, Hiroshi Kubota, Mariko Mine, Yasuhiro Matsuoka, Hiroshi Mukae, Kazuhiro Nagata and Shigeru Kohno
Organizer
European Respiratory Society
Place of Presentation
スペイン、バルセロナ
Related Report
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