Developing a novel therapy for Parkinson disease using mesenchymal cell-derived glial cells
| Project/Area Number |
25860716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
Matsuse Dai 九州大学, 医学(系)研究科(研究院), 助教 (70596395)
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| Research Collaborator |
OGATA HIDENORI
FUJITA ATSUSHI
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞移植治療 / 間葉系細胞 / シュワン細胞 / Muse細胞 / パーキンソン病 / シュワンン細胞 / 片側パーキンソン病モデルラット |
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| Outline of Final Research Achievements |
At first, we induced to differentiate Schwann cells (BM-SCs) from bone marrow-derived mesenchymal cells (MSCs) of Wistar rats by adding several trophic factors. Hemiparkinsonian rats were induced, and cells were engrafted in the affected portion of the striatum. Immunohistochemical study indicated that transplanted cells had lost the characteristic of Schwann cells after transplantation and then been eliminated.
Then we decided to use Multi-lineage differentiating Stress Enduring (Muse) cells for transplantation. Muse cells were obtained from human bone marrow stem cells. We confirmed their expression of immature markers and ability of triploblastic differentiation. We will continue to develop the novel therapy for Parkinson disease with Muse cells.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Anti-neurofascin antibody in patients with combined central and peripheral demyelination2013
Author(s)
Nobutoshi Kawamura, Ryo Yamasaki, Tomomi Yonekawa, Takuya Matsushita, Susumu Kusunoki, Shigemi Nagayama, Yasuo Fukuda, Hidenori Ogata, Dai Matsuse, Hiroyuki Murai, Jun-ichi Kira
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Journal Title
Neurology
Volume: 81
Issue: 8
Pages: 714-722
DOI
Related Report
Peer Reviewed
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
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Journal Title
J Clin Invest
Volume: 123(1)
Issue: 1
Pages: 272-284
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: 22(9)
Issue: 9
Pages: 1613-25
DOI
Related Report
Peer Reviewed
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[Presentation] Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy2015
Author(s)
Ogata H, Yamasaki R, Hiwatashi A, Oka N, Kawamura N, Matsuse D, Kuwahara M, Suzuki H, Kusunoki S, Fujimoto Y, Ikezoe K, Kishida H, Tanaka F, Matsushita T, Murai H, Kira J.
Organizer
American Neurological Association 2015 Annual Meeting
Place of Presentation
Chicago
Year and Date
2015-09-28
Related Report
Int'l Joint Research
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[Presentation] Combined Central and Peripheral Demyelination: Diagnostic Value of Anti-Neurofascin Antibody and the First Nationwide Survey In Japan2013
Author(s)
Ogata H, Yamasaki R, Matsuse D, Kawamura N, Yonekawa T, Matsushita T, Imamura S, Kusunoki S, Nagayama S, Fukuda Y, Murai H, Kira JI
Organizer
the 6th Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
Place of Presentation
Kyoto
Related Report
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