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Developing a novel therapy for Parkinson disease using mesenchymal cell-derived glial cells

Research Project

Project/Area Number 25860716
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionKyushu University

Principal Investigator

Matsuse Dai  九州大学, 医学(系)研究科(研究院), 助教 (70596395)

Research Collaborator OGATA HIDENORI  
FUJITA ATSUSHI  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords細胞移植治療 / 間葉系細胞 / シュワン細胞 / Muse細胞 / パーキンソン病 / シュワンン細胞 / 片側パーキンソン病モデルラット
Outline of Final Research Achievements

At first, we induced to differentiate Schwann cells (BM-SCs) from bone marrow-derived mesenchymal cells (MSCs) of Wistar rats by adding several trophic factors. Hemiparkinsonian rats were induced, and cells were engrafted in the affected portion of the striatum. Immunohistochemical study indicated that transplanted cells had lost the characteristic of Schwann cells after transplantation and then been eliminated.
Then we decided to use Multi-lineage differentiating Stress Enduring (Muse) cells for transplantation. Muse cells were obtained from human bone marrow stem cells. We confirmed their expression of immature markers and ability of triploblastic differentiation. We will continue to develop the novel therapy for Parkinson disease with Muse cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Book (7 results)

  • [Journal Article] A nationwide survey of combined central and peripheral demyelination in Japan.2015

    • Author(s)
      Hidenori Ogata
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 未定 Pages: 29-36

    • DOI

      10.1136/jnnp-2014-309831

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy.2015

    • Author(s)
      Ogata H, et al
    • Journal Title

      Ann Clin Transl Neurol.

      Volume: 2 Issue: 10 Pages: 960-971

    • DOI

      10.1002/acn3.248

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased serum vitamin D levels in Japanese patients with multiple sclerosis.2015

    • Author(s)
      Niino M, Sato S, Fukazawa T, Masaki K, Miyazaki Y, Matsuse D, Yamasaki R, Takahashi E, Kikuchi
    • Journal Title

      Journal of neuroimmunology

      Volume: 279 Pages: 40-45

    • DOI

      10.1016/j.jneuroim.2015.01.007

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells as a source of Schwann cells: their anticipated used in perioheral nerve regeneration.2015

    • Author(s)
      Wakao S, Matsuse D, Dezawa M.
    • Journal Title

      Cells Tissues Organs

      Volume: 200 Issue: 1 Pages: 1-11

    • DOI

      10.1159/000368188

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripheral blood T cell dynamics predict relapse in multiple sclerosis patients on fingolimod.2015

    • Author(s)
      Song Z, Yamasaki R, Kawano Y, Sato S, Masaki K, Yoshimura S, Matsuse D, Murai H, Matsushita T,
    • Journal Title

      PLoS One.

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS:2014

    • Author(s)
      Uehara R, Yamashita K, Hiwatashi A, Togao O, Kikuchi K, Yokoyama J, Matsuse D, Yoshiura T, Honda
    • Journal Title

      Brain and behavior

      Volume: 4 Issue: 6 Pages: 798-800

    • DOI

      10.1002/brb3.282

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-neurofascin antibody in patients with combined central and peripheral demyelination2013

    • Author(s)
      Nobutoshi Kawamura, Ryo Yamasaki, Tomomi Yonekawa, Takuya Matsushita, Susumu Kusunoki, Shigemi Nagayama, Yasuo Fukuda, Hidenori Ogata, Dai Matsuse, Hiroyuki Murai, Jun-ichi Kira
    • Journal Title

      Neurology

      Volume: 81 Issue: 8 Pages: 714-722

    • DOI

      10.1212/wnl.0b013e3182a1aa9c

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chharacteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis2013

    • Author(s)
      Matsushita T, Tateishi T, Isobe N, Yonekawa T, Yamasaki R, Murai H, Kira J
    • Journal Title

      PLos ONE

      Volume: 8 Issue: 4 Pages: e61835-e61835

    • DOI

      10.1371/journal.pone.0061835

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013

    • Author(s)
      Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
    • Journal Title

      J Clin Invest

      Volume: 123(1) Issue: 1 Pages: 272-284

    • DOI

      10.1172/jci62516

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment with basic fibroblast growth factor-incorporated gelatin hydrogel does not exacerbate mechanical allodynia after spinal cord contusion injury in rats2013

    • Author(s)
      Furuya T, Hashimoto M, Koda M, Murata A, Okawa A, Dezawa M, Matsuse D, Tabata Y, Takahashi K, Yamazaki M
    • Journal Title

      J Spinal Cord Med

      Volume: 36(2) Issue: 2 Pages: 134-9

    • DOI

      10.1179/2045772312y.0000000030

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013

    • Author(s)
      Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
    • Journal Title

      Cell Transplant

      Volume: 22(9) Issue: 9 Pages: 1613-25

    • DOI

      10.3727/096368912x658791

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy2015

    • Author(s)
      Ogata H, Yamasaki R, Hiwatashi A, Oka N, Kawamura N, Matsuse D, Kuwahara M, Suzuki H, Kusunoki S, Fujimoto Y, Ikezoe K, Kishida H, Tanaka F, Matsushita T, Murai H, Kira J.
    • Organizer
      American Neurological Association 2015 Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗neurofascin 155抗体陽性CIDPの臨床的特徴2015

    • Author(s)
      緒方 英紀,山﨑 亮,樋渡 昭雄,岡 伸幸,河村 信利,松瀬 大,桑原 基,鈴木 秀和,楠 進,池添 浩二,岸田 日帯,田中 章景,松下 拓也,村井 弘之,吉良 潤一
    • Organizer
      第26回 日本末梢神経学会学術集会
    • Place of Presentation
      松本
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Prevalence and features of anti-neurofascin 155 antibody-positive CIDP2015

    • Author(s)
      Ogata H, Yamasaki R, Matsuse D, Nobutoshi K, Takuya M, Kira J.
    • Organizer
      第56回日本神経学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Combined Central and Peripheral Demyelination: Diagnostic Value of Anti-Neurofascin Antibody and the First Nationwide Survey In Japan2015

    • Author(s)
      Ogata H, Matsuse D, Yamasaki R, Kawamura N, Matsushita T, Kira J
    • Organizer
      The 67th AAN Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2015-04-18 – 2015-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Combined Central and Peripheral Demyelination: Diagnostic Value of Anti-Neurofascin Antibody and2015

    • Author(s)
      Ogata H, Matsuse D, Yamasaki R, Kawamura N, Matsushita T, Kira J
    • Organizer
      The 67th AAN Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-Neurofascin Antibodies in the Inflammatory Demyelinating Diseases2014

    • Author(s)
      Ogata H, Yamasaki R, Matsuse D, Kawamura N, Matsushita T, Kira J
    • Organizer
      MSサマーカレッジ
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-02 – 2014-08-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症性脱髄性疾患における特異度の高い抗neurofascin抗体測定法の開発2014

    • Author(s)
      緒方英紀、松瀬大、河村信利、松下拓也、山﨑亮、吉良潤一
    • Organizer
      第55回 日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 中枢・末梢連合脱髄症(CCPD)における全国臨床疫学調査成績と抗neurofascin(NF)抗体陽性率の検討2014

    • Author(s)
      緒方 英紀, 松瀬 大, 松下 拓也, 河村 信利, 山崎 亮, 楠 進, 吉良 潤一
    • Organizer
      第111回日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Combined Central and Peripheral Demyelination: Diagnostic Value of Anti-Neurofascin Antibody and the First Nationwide Survey In Japan2013

    • Author(s)
      Ogata H, Yamasaki R, Matsuse D, Kawamura N, Yonekawa T, Matsushita T, Imamura S, Kusunoki S, Nagayama S, Fukuda Y, Murai H, Kira JI
    • Organizer
      the 6th Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Book] 免疫性神経疾患 III.中枢・末梢連合脱髄症 3. 中枢・末梢連合脱髄症の病態・診断・治療2015

    • Author(s)
      松瀬大, 緒方英紀, 吉良潤一
    • Total Pages
      5
    • Publisher
      日本臨牀
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Book] 骨格筋症候群(上)「限局性結節性筋炎」2015

    • Author(s)
      松瀬大, 吉良潤一
    • Total Pages
      5
    • Publisher
      日本臨牀
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Book] 多発性硬化症のフィンゴリモド療法.2014

    • Author(s)
      松瀬大, 吉良潤一
    • Total Pages
      2
    • Publisher
      Minds
    • Related Report
      2014 Research-status Report
  • [Book] 診療ガイドラインUP-TO-DATE2014-2015 中枢神経疾患 多発性硬化症・視神経脊髄2014

    • Author(s)
      松瀬大, 吉良潤一
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Research-status Report
  • [Book] 多発性硬化症のフィンゴリモド療法2014

    • Author(s)
      松瀬大, 吉良潤一
    • Total Pages
      2
    • Publisher
      Minds
    • Related Report
      2013 Research-status Report
  • [Book] 神経・精神疾患マニュアル V.よく見られる神経疾患 H.脱髄性疾患 「多発性硬化症」2013

    • Author(s)
      松瀬大, 吉良潤一
    • Total Pages
      2
    • Publisher
      南山堂
    • Related Report
      2013 Research-status Report
  • [Book] 多発性硬化症. 免疫性神経疾患ハンドブック2013

    • Author(s)
      松瀬大, 吉良潤一
    • Total Pages
      22
    • Publisher
      南江堂
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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