Optogenetic neuromodulation for Parkinson's disease

• Project/Area Number: 25860724
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: OYAMA Genko 順天堂大学, 医学部, 准教授 (00407256)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 光遺伝学 / ドパミン / 脳深部刺激療法 / チャネルロドプシン / アークロドプシン / 視床下核 / 淡蒼球内節 / チャネロドプシン / パーキンソン病 / 光刺激 / 電気刺激

Outline of Final Research Achievements

Deep brain stimulation (DBS), which utilizing electrical stimulation, has been clinically available for neuromodulation of Parkinson's disease. The electrical stimulation is nonselective, and the mechanism of DBS was unknown whether excitatory or inhibitory. In this study, we showed that dopamine release was controlled by illuminating light on dopaminergic neurons in which photosensitive protein was expressed. We established neuromodulation which can control dopaminergic release.

Research Products

• [Journal Article] Deep brain stimulation for tremor associated with underlying ataxia syndromes: a case series and discussion of issues. (2014)
  • Author(s): Oyama G, Thompson A, Foote KD, Limotai N, Abd-El-Barr M, Maling N, Malaty IA, Rodriguez RL, Subramony SH, Ashizawa T, Okun MS.
  • Journal Title: Tremor Other Hyperkinet Mov Volume: 4
  • DOI: 10.7916/D8542KQ5
  • Peer Reviewed / Open Access
• [Journal Article] Low-frequency versus high-frequency subthalamic nucleus deep brain stimulation on postural control and gait in Parkinson's disease: a quantitative study. (2014)
  • Author(s): Vallabhajosula S, Haq IU, Hwynn N, Oyama G, Okun M, Tillman MD, Hass CJ.
  • Journal Title: Brain Stimul Volume: 8 Issue: 1 Pages: 64-75
  • DOI: 10.1016/j.brs.2014.10.011
  • Peer Reviewed
• [Journal Article] Rescue GPi-DBS for a Stroke-associated Hemiballism in a Patient with STN-DBS (2014)
  • Author(s): Oyama, G. Maling, N. Avila-Thompson, A. Zeilman, P. R. Foote, K. D. Malaty, I. A. Rodriguez, R. L. Okun, M. S.
  • Journal Title: Tremor Other Hyperkinet Mov (N Y) Volume: 4
  • DOI: 10.7916/D8XP72WF
  • Peer Reviewed
• [Journal Article] Posterior Subthalamic Area Deep Brain Stimulation for Fragile X-Associated Tremor/Ataxia Syndrome (2014)
  • Author(s): Oyama, G. Umemura, A. Shimo, Y. Nishikawa, N. Nakajima, A. Jo, T. Nakajima, M. Ishii, H. Yamada, D. Takanashi, M. Arai, H. Nanba, E. Hattori, N.
  • Journal Title: Neuromodulation Volume: - Issue: 8 Pages: 721-723
  • DOI: 10.1111/ner.12150
  • Peer Reviewed
• [Journal Article] A Novel DYT-5 Mutation with Phenotypic Variability within a Colombian Family (2013)
  • Author(s): Bernal-Pacheco, O. Oyama, G. Briton, A. Singleton, A. B. Fernandez, H. H. Rodriguez, R. L. Malaty, I. A. Okun, M. S.
  • Journal Title: Tremor Other Hyperkinet Mov (N Y) Volume: 3
  • Peer Reviewed
• [Journal Article] Mechanism of action for deep brain stimulation and electrical neuro-network modulation (ENM) (2013)
  • Author(s): Okun, M. S. Oyama, G.
  • Journal Title: Rinsho Shinkeigaku Volume: 53 Pages: 691-694
  • Peer Reviewed
• [Journal Article] Deep Brain Stimulation May Improve Quality of Life in People With Parkinson's Disease Without Affecting Caregiver Burden (2013)
  • Author(s): Oyama, G. Okun, M. S. Schmidt, P. Troster, A. I. Nutt, J. Go, C. L. Foote, K. D. Malaty, I. A.
  • Journal Title: Neuromodulation Volume: - Issue: 2 Pages: 126-132
  • DOI: 10.1111/ner.12097
  • Peer Reviewed
• [Journal Article] Validity of single tract microelectrode recording in subthalamic nucleus stimulation (2013)
  • Author(s): Umemura, A. Oka, Y. Yamada, K. Oyama, G. Shimo, Y. Hattori, N.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 53 Pages: 821-827
  • Peer Reviewed
• [Journal Article] Update on deep brain stimulation for movement disorders (2013)
  • Author(s): Umemura, A. Oyama, G. Shimo, Y. Hattori, N.
  • Journal Title: Rinsho Shinkeigaku Volume: 53 Pages: 911-914
  • NAID: 130004505468
• [Presentation] Optogenetic Dopaminergic Stimulation in Mice (2014)
  • Author(s): Oyama G, Jo T, Yoshimi K, Sato S, Dawson TM, Shimo Y, Hattori N
  • Organizer: 4th Asian and Oceanian Parkinson’s and Movement Disorders Congress
  • Place of Presentation: Pataya
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Optogenetic Dopaminergic Stimulation in Mice (2014)
  • Author(s): Jo T, Oyama G, Yoshimi K, Sato S, Dawson TM, Nakajima A, Umemura A, Shimo Y, Hattori N
  • Organizer: 18th international Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Stockholm
  • Year and Date: 2014-06-08 – 2014-06-12
• [Presentation] Optogenetic Dopaminergic Stimulation in Mice (2014)
  • Author(s): T. Jo, G. Oyama, K. Yoshimi, S. Sato, TM Dawson, A. Nakajima, A. Umemura, Y. Shimo, N. Hattori
  • Organizer: 18TH INTERNATIONAL CONGRESS OF PARKINSON'S DISEASE AND MOVEMENT DISORDERS
  • Place of Presentation: Stockholm
• [Presentation] Posterior Subthalamic Area Deep Brain Stimulation in a Case with Fragile X–Associated Tremor/Ataxia Syndrome (2013)
  • Author(s): G. Oyama, A. Umemura, N. Nishikawa, A. Nakajima, T. Jo, M. Nakajima, H. Ishii, Y. Shimo, H. Arai, N. Hattori
  • Organizer: 17TH INTERNATIONAL CONGRESS OF PARKINSON'S DISEASE AND MOVEMENT DISORDERS
  • Place of Presentation: Sydney