The glycosphingolipid-mediated recognition of mycobacteria by human phagocytes
Project/Area Number |
25860831
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 病原性抗酸菌 / リポアラビノマンナン / 好中球 / ラクトシルセラミド / 貪食 / 食胞成熟阻害 / 食胞成熟 / 抗酸菌 |
Outline of Final Research Achievements |
Pathogenic mycobacteria such as Mycobacterium tuberculosis cause phagosomal maturation (phagosome-lysosome fusion) arrest. In this study, we aimed to elucidate the mechanism of glycosphingolipid-mediated mycobacterial recognition. Our results showed that mycobacterial LAM bound to lactosylceramide (LacCer), and affected LacCer-mediated phagosomal maturation in human neutrophils. These results provide new insights into how pathogenic mycobacteria inhibit phagosome-lysosome fusion.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Properties and functions of lactosylceramide from mouse neutrophils2015
Author(s)
Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K
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Journal Title
Glycobiology
Volume: 25
Issue: 6
Pages: 655-668
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells.2015
Author(s)
Chiricozzi E, Ciampa MG, Brasile G, Compostella F, Prinetti A, Nakayama H, Ekyalongo RC, Iwabuchi K, Sonnino S, Mauri L
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Journal Title
Journal of Lipid Research
Volume: 56
Issue: 1
Pages: 129-41
DOI
Related Report
Peer Reviewed
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[Journal Article] Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate2014
Author(s)
Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K.
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Journal Title
PLoS One.
Volume: 9(2)
Issue: 2
Pages: 89402-89402
DOI
Related Report
Peer Reviewed / Open Access
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