An early and non-invasive diagnosis of histiocytic necrotizing lymphadenitis
Project/Area Number |
25860868
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Kyushu University |
Principal Investigator |
MASATAKA Ishimura 九州大学, 医学(系)研究科(研究院), 助教 (10448417)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 組織球性壊死性リンパ節炎 / 菊池病 / 早期診断 / インターフェロン / インターフェロン誘導遺伝子 / 自己炎症性疾患 / 壊死性リンパ節炎 / 迅速診断 / 定量PCR |
Outline of Final Research Achievements |
Histiocytic necrotizing lymphadenitis (HNL), also called Kikuchi-Fujimoto disease, is a benign, self-limiting inflammatory disease with fever and painful cervical lymphadenopathy of unknown etiology. A lymph node biopsy is required for the definitive diagnosis because of no specific symptoms or laboratory findings for HNL. We investigated genes specifically expressed in the patients by analyzing whole transcriptome using microarray analysis of peripheral blood mononuclear cells (PBMC). The expression levels of the up-regulated genes by microarray were verified by quantitative PCR. H The discriminant analysis using the expression levels of these five genes distinguished HNL with 84 % accuracy. An analysis of the gene expression profile of PBMC may provide a rapid non-invasive diagnosis.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome2014
Author(s)
Yamamura K, Takada H, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Morihana E, Ohga S, Hara T
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Journal Title
Rheumatology
Volume: 53
Issue: 10
Pages: 1783-1787
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Paediatric presentation and outcome of congenital protein C deficiency in Japan.2013
Author(s)
Ohga S, Kang D, Kinjo T, Ochiai M, Doi T, Ishimura M, Kayamori Y, Urata M, Yamamoto J, Suenobu SI, Kanegane H, Ikenoue T, Shirahata A, Hara T.
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Journal Title
Haemophilia
Volume: 19
Issue: 3
Pages: 378-384
DOI
Related Report
Peer Reviewed
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[Journal Article] The identification of a novel splicing mutation in C1qB in a Japanese family with C1q deficiency: a case report2013
Author(s)
Higuchi Y, Shimizu J, Hatanaka M, Kitano E, Kitamura H, Takada H, Ishimura M, Hara T, Ohara O, Asagoe K, Kubo T
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Journal Title
Pediatr Rheumatol Online J
Volume: 28
Issue: 1
Pages: 41-41
DOI
Related Report
Peer Reviewed
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[Book] 小児内科2014
Author(s)
石村匡崇、高田英俊、原寿郎
Total Pages
5
Publisher
東京医学社
Related Report