Role of cardiac fibroblasts on cardiac development and differentiation during fetal period
| Project/Area Number |
25860885
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
AKAIKE Toru 東京慈恵会医科大学, 医学部, 助教 (20647101)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 線維芽細胞 / 心臓線維芽細胞 |
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| Outline of Final Research Achievements |
Cardiac fibroblasts contribute to cardiac hypertrophy and increases of cardiac function, not only fibrosis and scarring in heart. However, role of cardiac fibroblasts during fetal period still remains unclear. We then tried to elucidate whether fetal cardiac fibroblasts regulated proliferation and differentiation of cardiomyocytes. We performed primary culture in fetal and neonatal rat heart, and determined cell-cycle related genes by qRT-PCR analysis. Expressions of CDK2 and cyclin D1 mRNA in cardiomyocytes co-cultured with fetal cardiac fibroblasts were significantly higher than that of neonatal cardiac fibroblasts. We found that fetal cardiac fibroblasts may contribute to cardiomyocyte proliferation.
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Report
(3 results)
Research Products
(7 results)
