| Project/Area Number |
25860956
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ICHIHARA ASAKO 熊本大学, 大学院生命科学研究部, 助教 (20635784)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乾癬 / microRNA / 薬疹 / 疾患マーカー / 尋常性乾癬 / 重症薬疹 |
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| Outline of Final Research Achievements |
There were several overexpressed or suppressed microRNAs specifically in the skin, sera and hair of psoriasis patients. Especially, the hair root miR-19a levels, regulatory microRNA of TNF-α, were significantly up-regulated only in psoriasis compared with normal controls. Investigation of microRNA in psoriasis may lead to a new disease activity marker. Furthermore, we also investigate the microRNAs in severe drug eruptions as contorols of psoriasis. Our results indicated that downregulated BCL2L10 caused by miR-18a-5p overexpression mediates intrinsic keratinocyte apoptosis in patients with toxic epidermal necrolysis. Serum miR-18a-5p levels can be a useful disease marker for drug eruptions.
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