The role of the microRNA and the signal pathway in psoriasis

• Project/Area Number: 25860956
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: ICHIHARA ASAKO 熊本大学, 大学院生命科学研究部, 助教 (20635784)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 乾癬 / microRNA / 薬疹 / 疾患マーカー / 尋常性乾癬 / 重症薬疹

Outline of Final Research Achievements

There were several overexpressed or suppressed microRNAs specifically in the skin, sera and hair of psoriasis patients. Especially, the hair root miR-19a levels, regulatory microRNA of TNF-α, were significantly up-regulated only in psoriasis compared with normal controls. Investigation of microRNA in psoriasis may lead to a new disease activity marker. Furthermore, we also investigate the microRNAs in severe drug eruptions as contorols of psoriasis. Our results indicated that downregulated BCL2L10 caused by miR-18a-5p overexpression mediates intrinsic keratinocyte apoptosis in patients with toxic epidermal necrolysis. Serum miR-18a-5p levels can be a useful disease marker for drug eruptions.

Research Products

• [Journal Article] Case of disseminated cutaneous Mycobacterium chelonae infection mimicking cutaneous vasculitis. (2014)
  • Author(s): Ichihara A, Jinnin M, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol. Volume: 41 Issue: 5 Pages: 414-7
  • DOI: 10.1111/1346-8138.12459
  • Peer Reviewed
• [Journal Article] Increased CCL22 expression in psoriatic skin predicts a good response to infliximab therapy. (2014)
  • Author(s): Kusumoto S, Kajihara I, Nagamoto E, Makino K, Ichihara A, Aoi J, Johno T, Makino T, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: Br J Dermatol. Volume: 171 Issue: 5 Pages: 1259-61
  • DOI: 10.1111/bjd.13091
  • Peer Reviewed
• [Journal Article] Immunoglobulin G4-related disease in a psoriasis vulgaris patient treated with ustekinumab. (2014)
  • Author(s): Kajihara I, Makino K, Ichihara A, Fukushima S, Jinnin M, Hirooka S, Kojima K, Kourogi H, Ihn H.
  • Journal Title: J Dermatol. Volume: 41 Issue: 7 Pages: 670-1
  • DOI: 10.1111/1346-8138.12528
  • Peer Reviewed
• [Journal Article] The expression profile of the toll-like receptor family in scleroderma dermal fibroblasts. (2014)
  • Author(s): Sakoguchi A, Nakayama W, Jinnin M, Wang Z, Yamane K, Aoi J, Makino K, Kajihara I, Ichihara A, Makino T, Fukushima S, Sakai K, Inoue Y, Ihn H.
  • Journal Title: Clin Exp Rheumatol. Volume: 32
  • Peer Reviewed
• [Journal Article] Clinical significance of serum vascular endothelial-cadherin levels in inflammatory skin diseases. (2014)
  • Author(s): Kuriyama H, Jinnin M, Kanemaru H, Ichihara A, Fujisawa A, Moriya C, Fukushima S, Ihn H.
  • Journal Title: Ann Dermatol. Volume: 26 Issue: 4 Pages: 536-8
  • DOI: 10.5021/ad.2014.26.4.536
  • Peer Reviewed
• [Journal Article] Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients (2014)
  • Author(s): Takamitsu Makino; Masatoshi Jinnin; Mitsuhiko Etoh; Keitaro Yamane; Ikko Kajihara; Katsunari Makino; Asako Ichihara; Toshikatsu Igata; Keisuke Sakai; Satoshi Fukushima;
  • Journal Title: European Journal of Dermatology Volume: 24(4) Issue: 4 Pages: 760-6
  • DOI: 10.1684/ejd.2014.2384
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions. (2014)
  • Author(s): Ichihara A, Wang Z, Jinnin M, Izuno Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Allergy Clin Immunol. Volume: 133 Issue: 4 Pages: 1065-74
  • DOI: 10.1016/j.jaci.2013.09.019
  • Peer Reviewed
• [Journal Article] Analysis of expression pattern of serum microRNA levels in patients with psoriasis. (2014)
  • Author(s): Koga Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol Sci. Volume: 74 Issue: 2 Pages: 170-1
  • DOI: 10.1016/j.jdermsci.2014.01.005
  • Peer Reviewed
• [Journal Article] Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. (2014)
  • Author(s): Kajihara I, Jinnin M, Yamada S, Ichihara A, Makino T, Igata T, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: Mod Rheumatol. Volume: 24 Issue: 2 Pages: 374-6
  • DOI: 10.3109/14397595.2013.854065
  • Peer Reviewed
• [Journal Article] miR-424 levels in hair shaft are increased in psoriatic patients. (2014)
  • Author(s): Tsuru Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Ihn H.
  • Journal Title: J Dermatol. Volume: Epub ahead of print Issue: 5 Pages: 382-385
  • DOI: 10.1111/1346-8138.12460
  • Peer Reviewed
• [Journal Article] A case of psoriasis accompanied by arthritis after delivery. (2014)
  • Author(s): Kanemaru H, Jinnin M, Asao K, Ichihara A, Makino K, Kajihara I, Fujisawa A, Fukushima S, Ihn H.
  • Journal Title: Biosci Trends. Volume: 8 Pages: 64-7
  • NAID: 130003397286
  • Peer Reviewed
• [Journal Article] Detection of hair root miR-19a as a novel diagnostic marker for psoriasis. (2013)
  • Author(s): Hirao H, Jinnin M, Ichihara A, Fujisawa A, Makino K, Kajihara I, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Eur J Dermatol. Volume: 23 Issue: 6 Pages: 807-11
  • DOI: 10.1684/ejd.2013.2190
  • Peer Reviewed
• [Journal Article] Proportion of Lymphocytic Inflammation with CD123 Positive Cells in Lupus Erythematous Profundus Predict a Clinical Response to Treatment. (2013)
  • Author(s): Miyashita A, Fukushima S, Makino T, Yoshino Y, Yamashita J, Honda N, Aoi J, Ichihara A, Jinnin M, Inoue Y, Ihn H.
  • Journal Title: Acta Dermato-Venereologica Volume: 17 Issue: 5 Pages: 563-567
  • DOI: 10.2340/00015555-1777
  • Peer Reviewed
• [Presentation] Upregulation of miR-18a is associated with keratinocyte apoptosis in toxic epidermal necrolysis (2013)
  • Author(s): A. Ichihara, M. Jinnin, K. Sakai, S. Masuguchi, S. Fukushima, H. Ihn
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] 血管炎と鑑別を要したM. chelonae感染症の1例 (2013)
  • Author(s): 市原 麻子、牧野 貴充、境 恵祐、神人 正寿、福島 聡、井上 雄二、尹 浩信
  • Organizer: 第77回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 大宮、埼玉、大宮ソニックシティー