A research of melanoma progression via CCR5 axis

• Project/Area Number: 25860977
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: HINO Ryosuke 産業医科大学, 医学部, 非常勤医師 (30446116)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 悪性黒色腫 / ケモカイン受容体

Outline of Final Research Achievements

We could not detect any difference of prognosis or progression free survival between CCR5 expression is present or not in the resected specimens of primary tumors of melanoma patients treated in our hospital. To detect the factor for augmentation of CCR5 expression, we focused on inflammatory cytokines and checked IL-17A and TNF-α in the melanoma patients' serum. Serum IL-17A level of patient in stage 4 of CCR5 positive group is higher than negative group. However, there were no difference between positive or negative in TNF-α level in the melanoma patients' serum.