Functional analysis of miR-137, a risk gene for schizophrenia
Project/Area Number |
25861003
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | Osaka University |
Principal Investigator |
UMEDA-YANO Satomi 大阪大学, 医学(系)研究科(研究院), 特任研究員 (00625329)
|
Research Collaborator |
HASHIMOTO Ryota 大阪大学, 大学院連合小児発達学研究科, 准教授 (10370983)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | miR-137 / 統合失調症 / 神経細胞 / 分化 / 突起進展 / マウス初代神経細胞 / 中間表現型 / 遺伝子 / SH-SY5Y細胞 / レチノイン酸 / BDNF |
Outline of Final Research Achievements |
A recently completed genome-wide association study (GWAS) showed that single-nucleotide polymorphisms (SNPs) in the MIR137 gene, which encodes one of the brain-enriched miRNAs (miR-137), is highly associated with schizophrenia. In addition, the GWAS showed that not only miR-137 but also putative target genes of miR-137 (CSMD1, C10orf26, CACNA1C and TCF4) have significant associations with schizophrenia. Further, genes which have been reported to be associated with schizophrenia are enriched in predicted miR-137 target genes. In this study, we investigated the role of miR-137 and its target genes during neuronal differentiation. Our results showed that miR-137 expression increased during neuronal differentiation, but miR-137 does not seem to be involved in it. Further, miR-137 does not regulate the expression of CSMD1, C10orf26, CACNA1C and TCF4 in neuroblastoma cells and primary neurons.
|
Report
(3 results)
Research Products
(25 results)
-
[Journal Article] Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment.2014
Author(s)
Yamamori H, Hashimoto R, Fujita Y, Numata S, Yasuda Y, Fujimoto M, Ohi K, Umeda-Yano S, Ito A, Ohmori T, Hashimoto K, Takeda M.
-
Journal Title
Neurosci Lett.
Volume: 582
Pages: 93-8
DOI
Related Report
Peer Reviewed
-
[Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia.2014
Author(s)
Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
-
Journal Title
Psychiatry Clin Neurosci.
Volume: in press
Issue: 7
Pages: 534-541
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume.2014
Author(s)
Ohi K, Hashimoto R, Ikeda M, Yamashita F, Fukunaga M, Nemoto K, Ohnishi T, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Iwata N, Weinberger DR, Takeda M.
-
Journal Title
Cortex
Volume: 58
Pages: 23-6
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening.2012
Author(s)
Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
-
Journal Title
Schizophrenia Bulletin
Volume: 39
Issue: 3
Pages: 39-39
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-