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Functional analysis of miR-137, a risk gene for schizophrenia

Research Project

Project/Area Number 25861003
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

UMEDA-YANO Satomi  大阪大学, 医学(系)研究科(研究院), 特任研究員 (00625329)

Research Collaborator HASHIMOTO Ryota  大阪大学, 大学院連合小児発達学研究科, 准教授 (10370983)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsmiR-137 / 統合失調症 / 神経細胞 / 分化 / 突起進展 / マウス初代神経細胞 / 中間表現型 / 遺伝子 / SH-SY5Y細胞 / レチノイン酸 / BDNF
Outline of Final Research Achievements

A recently completed genome-wide association study (GWAS) showed that single-nucleotide polymorphisms (SNPs) in the MIR137 gene, which encodes one of the brain-enriched miRNAs (miR-137), is highly associated with schizophrenia. In addition, the GWAS showed that not only miR-137 but also putative target genes of miR-137 (CSMD1, C10orf26, CACNA1C and TCF4) have significant associations with schizophrenia. Further, genes which have been reported to be associated with schizophrenia are enriched in predicted miR-137 target genes. In this study, we investigated the role of miR-137 and its target genes during neuronal differentiation. Our results showed that miR-137 expression increased during neuronal differentiation, but miR-137 does not seem to be involved in it. Further, miR-137 does not regulate the expression of CSMD1, C10orf26, CACNA1C and TCF4 in neuroblastoma cells and primary neurons.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment.2014

    • Author(s)
      Yamamori H, Hashimoto R, Fujita Y, Numata S, Yasuda Y, Fujimoto M, Ohi K, Umeda-Yano S, Ito A, Ohmori T, Hashimoto K, Takeda M.
    • Journal Title

      Neurosci Lett.

      Volume: 582 Pages: 93-8

    • DOI

      10.1016/j.neulet.2014.08.052

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia.2014

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: in press Issue: 7 Pages: 534-541

    • DOI

      10.1111/pcn.12165

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cognitive inflexibility in Japanese adolescents and adults with autism spectrum disorders.2014

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Takeda M.
    • Journal Title

      World J Psychiatry.

      Volume: 22 Issue: 2 Pages: 42-8

    • DOI

      10.5498/wjp.v4.i2.42

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume.2014

    • Author(s)
      Ohi K, Hashimoto R, Ikeda M, Yamashita F, Fukunaga M, Nemoto K, Ohnishi T, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Iwata N, Weinberger DR, Takeda M.
    • Journal Title

      Cortex

      Volume: 58 Pages: 23-6

    • DOI

      10.1016/j.cortex.2014.05.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between genetic polymorphism rs2952768, close to the METTL21A and CREB1 genes, and intellectual ability in healthy subjects.2014

    • Author(s)
      Nishizawa D, et al.
    • Journal Title

      Journal of Addiction Research & Therapy

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Imaging genetics and psychiatric disorders.2014

    • Author(s)
      Hashimoto R, et al.
    • Journal Title

      Current Molecular Medicine

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia.2014

    • Author(s)
      Umeda-Yano S, et al.
    • Journal Title

      Neuroscience Letters

      Volume: in press Pages: 12-6

    • DOI

      10.1016/j.neulet.2014.03.031

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A functional polymorphism of the GTP cyclohydrolase I gene predicts attention performance2014

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Horiguchi M, Takeda M, Ichinose H
    • Journal Title

      Neurosci Lett

      Volume: 566 Pages: 46-49

    • DOI

      10.1016/j.neulet.2014.02.019

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects intelligence quotient in schizophrenia2014

    • Author(s)
      Horiguchi M, Ohi K, Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68(6) Issue: 6 Pages: 456-62

    • DOI

      10.1111/pcn.12157

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relation between remission status and attention in patients withn schizophrenia.2014

    • Author(s)
      Fukumoto M, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68(3) Pages: 234-41

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine.2013

    • Author(s)
      Yamamori H, et al.
    • Journal Title

      Neurosci Lett,

      Volume: 556( Pages: 37-41

    • DOI

      10.1016/j.neulet.2013.09.059

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of the NRGN gene on intellectual ability in schizophrenia.2013

    • Author(s)
      Ohi K, et al.
    • Journal Title

      Journal of Human Genetics,

      Volume: 58(10) Issue: 10 Pages: 700-5

    • DOI

      10.1038/jhg.2013.82

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia.2013

    • Author(s)
      Ohi K, et al.
    • Journal Title

      Behavioral and Brain Functions,

      Volume: 9(1) Issue: 1 Pages: 40-40

    • DOI

      10.1186/1744-9081-9-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of cognitive decline in schizophrenia.2013

    • Author(s)
      Hashimoto R, et al.
    • Journal Title

      Am J Psychiatry

      Volume: 170(6) Issue: 6 Pages: 683-4

    • DOI

      10.1176/appi.ajp.2013.12091228

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening.2012

    • Author(s)
      Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
    • Journal Title

      Schizophrenia Bulletin

      Volume: 39 Issue: 3 Pages: 39-39

    • DOI

      10.1093/schbul/sbs038

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 統合失調症患者由来サンプルを用いた統合失調症の病態解明研究2014

    • Author(s)
      橋本亮太、山森英長、梅田知美、藤本美智子、安田由華、伊藤彰、武田雅俊、
    • Organizer
      第11回NDDC-JSG会議
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 複数のバイオマーカーを用いた気分障害と統合失調症の補助診断方法確立の検討2014

    • Author(s)
      山森英長、橋本亮太、石間環、藤本美智子、安田由華、大井一高、梅田知美、伊藤彰、橋本謙二、武田雅俊、
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会
    • Place of Presentation
      奈良
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症の生物学的マーカーとしての眼球運動スコアの開発2014

    • Author(s)
      藤本美智子、橋本亮太、三浦健一郎、山森英長、安田由華、大井一高、梅田知美、岩瀬真生、武田雅俊、
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 治療抵抗性統合失調症への果てしなき挑戦:治療のゴールはどこにあるのか?2014

    • Author(s)
      橋本亮太、山森英長、藤本美智子、安田由華、大井一高、梅田知美、武田雅俊、
    • Organizer
      第110回日本精神神経学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intermediate phenotype studies in schizophrenia2014

    • Author(s)
      Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Takeda M.
    • Organizer
      29th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経細胞の分化における統合失調症リスク因子miR-137の役割、2013

    • Author(s)
      梅田知美、
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Book] ニューサイエンス社2014

    • Author(s)
      橋本亮太、山森英長、安田由華、大井一高、藤本美智子、梅田知美、武田雅俊、
    • Publisher
      イメージングジェネティクスで精神疾患に迫る、Medical Scienece Digest
    • Related Report
      2014 Annual Research Report
  • [Remarks] 分子精神医学研究グループ

    • Related Report
      2014 Annual Research Report
  • [Remarks] http://www.sp-web.sakura.ne.jp/lab/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 分子精神医学研究グループ

    • URL

      http://www.sp-web.sakura.ne.jp/lab/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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