Search of the diagnotic biomarkers for depression

• Project/Area Number: 25861009
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: SEGAWA MASAHIRO 広島大学, 医歯薬保健学研究院, 特任助教 (20457253)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: うつ病 / proBDNF / BDNFアンチセンス / ５－HTT / メチル化 / SLC6A4 / うつ病バイオマーカー / 血清pro-BDNF / セロトニントランスポーター / うつ病のバイオマーカー / DNAメチル化

Outline of Final Research Achievements

Comparison of the proBDNF (brain derived neurotrophic factor) density in the blood with the control (n=20) and the depression patient (n=5) didn't give us the significant difference. Leukocyte-derived BDNF antisense RNA was measured in real-time PCR. It was possible to measure with only the control (n=5). We had compared the methylation rate of CpG Island of SLC6A4 which is a manifested control part of a serotonin transporter (5-HTT) of the depression (n=50) with one of the control (n=50). We didn't have the result in line with expectations, but a possibility which can be the biomarker of the therapeutic responses to antidepressant.

Research Products

• [Journal Article] The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression (2014)
  • Author(s): Okada S, Morinobu S, et al
  • Journal Title: Journal of Psychiatric Research Volume: 53 Pages: 47-53
  • DOI: 10.1016/j.jpsychires.2014.02.002
  • Peer Reviewed