2014 Fiscal Year Final Research Report
Search of the diagnotic biomarkers for depression
Project/Area Number |
25861009
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Hiroshima University |
Principal Investigator |
SEGAWA MASAHIRO 広島大学, 医歯薬保健学研究院, 特任助教 (20457253)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | うつ病 / proBDNF / BDNFアンチセンス / 5-HTT / メチル化 / SLC6A4 |
Outline of Final Research Achievements |
Comparison of the proBDNF (brain derived neurotrophic factor) density in the blood with the control (n=20) and the depression patient (n=5) didn't give us the significant difference. Leukocyte-derived BDNF antisense RNA was measured in real-time PCR. It was possible to measure with only the control (n=5). We had compared the methylation rate of CpG Island of SLC6A4 which is a manifested control part of a serotonin transporter (5-HTT) of the depression (n=50) with one of the control (n=50). We didn't have the result in line with expectations, but a possibility which can be the biomarker of the therapeutic responses to antidepressant.
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Free Research Field |
うつ病
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