Search of the diagnotic biomarkers for depression
Project/Area Number |
25861009
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | Hiroshima University |
Principal Investigator |
SEGAWA MASAHIRO 広島大学, 医歯薬保健学研究院, 特任助教 (20457253)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | うつ病 / proBDNF / BDNFアンチセンス / 5-HTT / メチル化 / SLC6A4 / うつ病バイオマーカー / 血清pro-BDNF / セロトニントランスポーター / うつ病のバイオマーカー / DNAメチル化 |
Outline of Final Research Achievements |
Comparison of the proBDNF (brain derived neurotrophic factor) density in the blood with the control (n=20) and the depression patient (n=5) didn't give us the significant difference. Leukocyte-derived BDNF antisense RNA was measured in real-time PCR. It was possible to measure with only the control (n=5). We had compared the methylation rate of CpG Island of SLC6A4 which is a manifested control part of a serotonin transporter (5-HTT) of the depression (n=50) with one of the control (n=50). We didn't have the result in line with expectations, but a possibility which can be the biomarker of the therapeutic responses to antidepressant.
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Report
(3 results)
Research Products
(1 results)