| Project/Area Number |
25861017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University |
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Principal Investigator |
MURAYAMA KEITARO 九州大学, 医学(系)研究科(研究院), その他 (20645981)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 強迫症 / ワーキングメモリ / functional MRI / 強迫性障害 |
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| Outline of Final Research Achievements |
We compared the differences in brain activation using fMRI and N-back task performance between 13 patients and 17 normal controls and compared that in OCD patients before and after treatment. The correct answer rates of N-back task were no differences between OCD patients at the before treatment and normal controls (p=0.738). There, meanwhile, was significant difference between OCD patients at the before and after treatment (p=0.018). The patients showed greater activation in the left middle and superior frontal gyrus, right precuneus, bilateral inferior parietal lobe than the normal controls. The patients after the treatment showed lower activation than the patients before the treatment in the left inferior and superior parietal lobe, right precuneus, left middle frontal gyrus. These findings support that front-parietal region might compensate for the dysfunction of dorsolateral prefrontal cortex and anterior cingulate cortex which relate to central executive of working memory.
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