Brain activity in patients with OCD during visual working memory task: an fMRI study

• Project/Area Number: 25861017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: MURAYAMA KEITARO 九州大学, 医学(系)研究科(研究院), その他 (20645981)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 強迫症 / ワーキングメモリ / functional MRI / 強迫性障害

Outline of Final Research Achievements

We compared the differences in brain activation using fMRI and N-back task performance between 13 patients and 17 normal controls and compared that in OCD patients before and after treatment. The correct answer rates of N-back task were no differences between OCD patients at the before treatment and normal controls (p=0.738). There, meanwhile, was significant difference between OCD patients at the before and after treatment (p=0.018). The patients showed greater activation in the left middle and superior frontal gyrus, right precuneus, bilateral inferior parietal lobe than the normal controls. The patients after the treatment showed lower activation than the patients before the treatment in the left inferior and superior parietal lobe, right precuneus, left middle frontal gyrus. These findings support that front-parietal region might compensate for the dysfunction of dorsolateral prefrontal cortex and anterior cingulate cortex which relate to central executive of working memory.

Research Products

• [Journal Article] NMDA受容体機能調整作用を有する新たな強迫症治療への期待 (2014)
  • Author(s): 村山桂太郎、中尾智博
  • Journal Title: 臨床精神薬理 Volume: 17 Pages: 1525-1534
• [Journal Article] Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment. (2014)
  • Author(s): Okada K, Nakao T, Sanematsu H, Murayama K, Honda S, Tomita M, Togao O, Yoshiura T, Kanba S.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 印刷中 Issue: 7 Pages: 411-421
  • DOI: 10.1111/pcn.12269
  • Peer Reviewed / Open Access
• [Journal Article] 強迫性障害における脳画像研究と生物学的病態仮説 (2013)
  • Author(s): 村山桂太郎 中尾智博 神庭重信
  • Journal Title: 福岡医学雑誌 Volume: 104(5) Pages: 181-188
  • NAID: 120005315164
  • Peer Reviewed
• [Presentation] 強迫症とfronto-parietal network (2015)
  • Author(s): 村山桂太郎､中尾智博、富田真弓、實松寛晋、岡田佳代、本田慎一、猪狩圭介、桑野真澄 山田聖 神庭重信
  • Organizer: 第7回日本不安症学会学術大会
  • Place of Presentation: 広島
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] 強迫症における視覚的ワーキングメモリと脳賦活の変化について (2014)
  • Author(s): 村山桂太郎
  • Organizer: 精神疾患と認知機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-08
• [Presentation] N-back taskにおける強迫症患者の脳賦活について (2014)
  • Author(s): 村山桂太郎､中尾智博、富田真弓、實松晋寬、中川彰子、神庭重信
  • Organizer: 日本認知・行動療法学会第40回大会
  • Place of Presentation: 富山
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] Brain activity in drug-free patients with obsessive-compulsive disorder during visual working memory task: an fMRI study (2014)
  • Author(s): Murayama K, Nakao T, Tomita M, Sanematu H, Okada K, Honda S, Ikari K, Kuwano M, Nakagawa A, Kanba S
  • Organizer: World Psychiatric Association International Congress
  • Place of Presentation: Madrid
  • Year and Date: 2014-09-15 – 2014-09-19
• [Presentation] Alterations of the brain activation during N-back task in patients with OCD after 12weeks treatments. (2014)
  • Author(s): Murayama K, Nakao T, Tomita M, NakagawaA, Nakatani E, Nabeyama M, Yoshizato C, Sanematu H, Okada K, Honda S, Ikari K, Kuwano M, Kanba S
  • Organizer: Europian Association for Behavioural and Cognitive Therapies
  • Place of Presentation: The Hague
  • Year and Date: 2014-09-11 – 2014-09-14
• [Presentation] Brain activity in drug-free patients with obsessive-compulsive disorder during visual working memory task: an fMRI study (2014)
  • Author(s): K. Murayama, T. Nakao, M. Tomita, H. Sanematu, K. Okada, S. Honda, K. Ikari1, M. Kuwano, A. Nakagawa, S. Kanba
  • Organizer: 16th World Congress of Psychiatry
  • Place of Presentation: Madrid, Spain
• [Presentation] Grey matter abnormality in Checking-based Obsessive-Compulsive Disorder. (2013)
  • Author(s): Okada K, Nakao T, Yoshiura T, Sanematsu H, Murayama K, Honda S, Tomita M, Kanba S
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan
• [Presentation] White Matter Structural Changes of Obsessive-Compulsive disorder~ from the aspect of Diffusion Tensor Imaging. (2013)
  • Author(s): Okada K, Nakao T, Sanematsu H, Murayama K, Honda S, Kanba S
  • Organizer: 43rd Annual Congress of European Association for Behavioral and Cognitive Therapies
  • Place of Presentation: Marrakech, Morocco
• [Book] DSM-5を読み解く5 (2014)
  • Author(s): 村山桂太郎, 中尾智博
  • Total Pages: 5
  • Publisher: 中山書店