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The mechanism of hypersexuality in patient with dementia

Research Project

Project/Area Number 25861020
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKumamoto University

Principal Investigator

Yatabe Yusuke  熊本大学, 医学部附属病院, 非常勤診療医師 (50508637)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordshypersexuality / 不適切な性行動 / 認知症 / BPSD / 色情 / 介護負担度 / アルツハイマー病
Outline of Final Research Achievements

Patients with dementia occasionally exhibit inappropriate sexual behavior (ISB). Although ISB is one of the problematic symptoms for caregivers, little is known concerning the mechanism of ISB in dementia. The purpose of this study is to investigate the prevalence of ISB and factors related to it in patients with dementia. The sample consisted of 442 consecutive outpatients with dementia. We evaluated ISB by using an original question. Of the 442 patients with dementia, 16 (3.6%) showed ISB. The prevalence of ISB did not significantly differ by dementia type. Multiple logistic regression showed that ISB was significantly associated with male sex, high MMSE score, delusions, agitation, euphoria, antiparkinson drug use, and cholinesterase inhibitors use. Our results suggest that if patients with dementia present with ISB, we should consider reducing their dosage of antiparkinson drugs or cholinesterase inhibitors as well as treatment of delusions, agitation, and euphoria.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Relationship between dementia severity and behavioral and psychological symptoms of dementia in dementia with Lewy bodies and Alzheimer’s disease patients2015

    • Author(s)
      Hashimoto M, Ogawa Y, Yatabe Y, Ishikawa T, Fukuhara R, Kaneda K, Honda K, Yuki S, Imamura T, Ksazui H, Kamimura N, Shinagawa S, Mizukami K, Mori E, Ikeda M
    • Journal Title

      Dement Geriatr Cogn Disord Extra

      Volume: 5 Issue: 2 Pages: 244-52

    • DOI

      10.1159/000381800

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between dementia severity and behavioural and psychological symptoms in early-onset Alzheimer's disease.2015

    • Author(s)
      Tanaka H, Hashimoto M, Fukuhara R, Ishikawa T, Yatabe Y, Kaneda K, Yuuki S, Honda K, Matsuzaki S, Tsuyuguchi A, Hatada Y, Ikeda M.
    • Journal Title

      Psychogeriatrics

      Volume: - Issue: 4 Pages: 242-7

    • DOI

      10.1111/psyg.12108

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 本邦におけるFTDに対するoff-label処方の実態について2015

    • Author(s)
      品川俊一郎,矢田部裕介,繁信和恵,福原竜治,橋本 衛,池田 学,中山和彦
    • Journal Title

      Dementia Japan

      Volume: 29 Pages: 78-85

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Patient-Related Factors Associated With Depressive State in Caregivers of Patients With Dementia at Home.2014

    • Author(s)
      Hasegawa N, Hashimoto M, Koyama A, Ishikawa T, Yatabe Y, Honda K, Yuuki S, Araki K, Ikeda M.
    • Journal Title

      J Am Med Dir Assoc.

      Volume: 15(5) Issue: 5 Pages: 371.e15-371.e18

    • DOI

      10.1016/j.jamda.2014.02.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] コタール症候群と認知症の抑うつ2014

    • Author(s)
      藤瀬 昇,矢田部裕介,池田 学
    • Journal Title

      Dementia Japan

      Volume: 28 Pages: 245-251

    • Related Report
      2014 Research-status Report
  • [Journal Article] Efficacy of increasing donepezil in mild to moderate Alzheimer’s disease patients who show diminished response to 5mg donepezil: a preliminary study.2013

    • Author(s)
      Yatabe Y, Hashimoto M, Kaneda K, Honda K, Ogawa Y, Yuuki S, Ikeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 13(2) Issue: 2 Pages: 88-93

    • DOI

      10.1111/psyg.12004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 前頭側頭型認知症 vs. 躁病2013

    • Author(s)
      矢田部裕介, 池田 学
    • Journal Title

      精神科

      Volume: 23(6) Pages: 631-636

    • Related Report
      2013 Research-status Report
  • [Presentation] アルツハイマー病と色情2015

    • Author(s)
      矢田部裕介,橋本 衛,池田 学
    • Organizer
      第91回熊本精神神経学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-02-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Neural correlates of abnormal eating behaviors in semantic dementia –a preliminarily semi-quantitative analysis-2014

    • Author(s)
      Fukuhara R, Tanaka H, Hatada Y, Ishikawa T, Yatabe Y, Yuki S, Shiraishi S, Hirai T, Hashimoto M, Ikeda M
    • Organizer
      9th International Conference on Frontotemporal Dementias
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-08-23 – 2014-08-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 認知症における色情のメカニズム2013

    • Author(s)
      矢田部裕介, 橋本 衛, 矢野宏之, 池田 学
    • Organizer
      第18回日本神経精神医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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