The mechanism of hypersexuality in patient with dementia

• Project/Area Number: 25861020
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kumamoto University
• Principal Investigator: Yatabe Yusuke 熊本大学, 医学部附属病院, 非常勤診療医師 (50508637)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: hypersexuality / 不適切な性行動 / 認知症 / BPSD / 色情 / 介護負担度 / アルツハイマー病

Outline of Final Research Achievements

Patients with dementia occasionally exhibit inappropriate sexual behavior (ISB). Although ISB is one of the problematic symptoms for caregivers, little is known concerning the mechanism of ISB in dementia. The purpose of this study is to investigate the prevalence of ISB and factors related to it in patients with dementia. The sample consisted of 442 consecutive outpatients with dementia. We evaluated ISB by using an original question. Of the 442 patients with dementia, 16 (3.6%) showed ISB. The prevalence of ISB did not significantly differ by dementia type. Multiple logistic regression showed that ISB was significantly associated with male sex, high MMSE score, delusions, agitation, euphoria, antiparkinson drug use, and cholinesterase inhibitors use. Our results suggest that if patients with dementia present with ISB, we should consider reducing their dosage of antiparkinson drugs or cholinesterase inhibitors as well as treatment of delusions, agitation, and euphoria.

Research Products

• [Journal Article] Relationship between dementia severity and behavioral and psychological symptoms of dementia in dementia with Lewy bodies and Alzheimer’s disease patients (2015)
  • Author(s): Hashimoto M, Ogawa Y, Yatabe Y, Ishikawa T, Fukuhara R, Kaneda K, Honda K, Yuki S, Imamura T, Ksazui H, Kamimura N, Shinagawa S, Mizukami K, Mori E, Ikeda M
  • Journal Title: Dement Geriatr Cogn Disord Extra Volume: 5 Issue: 2 Pages: 244-52
  • DOI: 10.1159/000381800
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between dementia severity and behavioural and psychological symptoms in early-onset Alzheimer's disease. (2015)
  • Author(s): Tanaka H, Hashimoto M, Fukuhara R, Ishikawa T, Yatabe Y, Kaneda K, Yuuki S, Honda K, Matsuzaki S, Tsuyuguchi A, Hatada Y, Ikeda M.
  • Journal Title: Psychogeriatrics Volume: - Issue: 4 Pages: 242-7
  • DOI: 10.1111/psyg.12108
  • Peer Reviewed / Open Access
• [Journal Article] 本邦におけるFTDに対するoff-label処方の実態について (2015)
  • Author(s): 品川俊一郎，矢田部裕介，繁信和恵，福原竜治，橋本 衛，池田 学，中山和彦
  • Journal Title: Dementia Japan Volume: 29 Pages: 78-85
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Patient-Related Factors Associated With Depressive State in Caregivers of Patients With Dementia at Home. (2014)
  • Author(s): Hasegawa N, Hashimoto M, Koyama A, Ishikawa T, Yatabe Y, Honda K, Yuuki S, Araki K, Ikeda M.
  • Journal Title: J Am Med Dir Assoc. Volume: 15(5) Issue: 5 Pages: 371.e15-371.e18
  • DOI: 10.1016/j.jamda.2014.02.007
  • Peer Reviewed / Open Access
• [Journal Article] コタール症候群と認知症の抑うつ (2014)
  • Author(s): 藤瀬 昇，矢田部裕介，池田 学
  • Journal Title: Dementia Japan Volume: 28 Pages: 245-251
• [Journal Article] Efficacy of increasing donepezil in mild to moderate Alzheimer’s disease patients who show diminished response to 5mg donepezil: a preliminary study. (2013)
  • Author(s): Yatabe Y, Hashimoto M, Kaneda K, Honda K, Ogawa Y, Yuuki S, Ikeda M.
  • Journal Title: Psychogeriatrics Volume: 13(2) Issue: 2 Pages: 88-93
  • DOI: 10.1111/psyg.12004
  • Peer Reviewed
• [Journal Article] 前頭側頭型認知症 vs. 躁病 (2013)
  • Author(s): 矢田部裕介, 池田 学
  • Journal Title: 精神科 Volume: 23(6) Pages: 631-636
• [Presentation] アルツハイマー病と色情 (2015)
  • Author(s): 矢田部裕介，橋本 衛，池田 学
  • Organizer: 第91回熊本精神神経学会
  • Place of Presentation: 熊本
  • Year and Date: 2015-02-21
• [Presentation] Neural correlates of abnormal eating behaviors in semantic dementia –a preliminarily semi-quantitative analysis- (2014)
  • Author(s): Fukuhara R, Tanaka H, Hatada Y, Ishikawa T, Yatabe Y, Yuki S, Shiraishi S, Hirai T, Hashimoto M, Ikeda M
  • Organizer: 9th International Conference on Frontotemporal Dementias
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-08-23 – 2014-08-26
• [Presentation] 認知症における色情のメカニズム (2013)
  • Author(s): 矢田部裕介, 橋本 衛, 矢野宏之, 池田 学
  • Organizer: 第18回日本神経精神医学会
  • Place of Presentation: 大阪