| Project/Area Number |
25861023
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
ASAMI Takeshi 横浜市立大学, 附属病院, 講師 (70623057)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | パニック症 / MRI / 脳容積 / 皮質の厚み / 脳画像 / 自律神経機能 / パニック障害 |
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| Outline of Final Research Achievements |
Structural brain changes and their sex differences were evaluated to clarify neurological basis of panic disorder using MRI. Associations between their changes and autonomic functions, endocrine function, as well as clinical symptoms, were also evaluated. The results showed that significant gray matter volume reductions and thin cortical thickness were found in some brain regions, such as orbitofrontal gyrus, superior frontal gyrus, and superior temporal gyrus, in the patients with panic disorder compared with the healthy control subjects. Sex differences were confirmed that the female patients showed the more widespread gray matter volume reductions relative to the male patients. In terms of the physiological function, there were no differences in the autonomic functions or the endocrine function between the patients and the control subjects. No relationship was confirmed between the brain structural changes and the physiological function in the patients with panic disorder.
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