Investigation to elucidate the pathophysiology of schizophrenia using carbonyl stress biomarkers
| Project/Area Number |
25861040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Metropolitan Institute of Medical Science (2015)
Shinshu University (2013-2014) |
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Principal Investigator |
MIYASHITA Mitsuhiro 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (60532132)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | カルボニルストレス / 統合失調症 / ペントシジン / ビタミンB6 / 終末糖化産物 |
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| Outline of Final Research Achievements |
We investigated reproducibility of enhanced carbonyl stress in another new larger cohort of schizophrenic patients. As a result of the investigation, we found significant increase of pentosidine levels and decrease of serum pyridoxal in schizophrenia, respectively when compared to those of control subjects. In addition, we found that patients with enhanced carbonyl stress shared many clinical features with treatment-resistant schizophrenia. These include a higher proportion of inpatients, longer durations of hospitalization, and higher doses of antipsychotic medication, compared with patients without carbonyl stress. Interestingly, psychopathological symptoms showed a tendency towards negative association with serum vitamin B6 levels. Our results support the idea that treatment regimes reducing carbonyl stress, such as supplementation of pyridoxamine, could provide novel therapeutic benefits for this subgroup of patients.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Replication of enhanced carbonyl stress in a subpopulation of schizophrenia.2014
Author(s)
Miyashita M, Arai M, Yuzawa H, Niizato K, Oshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M
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Journal Title
Psychiatry and clinical neurosciences.
Volume: 68
Pages: 83-4
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical Features of Schizophrenia With Enhanced Carbonyl Stress2014
Author(s)
Miyashita M, Arai M, Kobori A, Ichikawa T, Toriumi K, Niizato K, Oshima, K, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M.
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Journal Title
Schizophrenia Bulletin
Volume: 40（５）
Pages: 1040-1046
DOI
Related Report
Peer Reviewed
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[Presentation] Clinical features of schizophrenia with enhanced carbonyl stress and potential therapeutic value of vitamin B62015
Author(s)
Mitsuhiro Miyashita, Makoto Arai, Akiko Kobori, Yasue Horiuchi, Kazuya Toriumi, Tomoe Ichikawa, Kazuhiro Niizato, Kenichi Oshima, Yuji Okazaki, Takeo Yoshikawa, Naoji Amano, Toshio Miyata, Masanari Itokawa.
Organizer
第10回日本統合失調症学会
Place of Presentation
東京 都市センターホテル, 東京都千代田区平河町2-4-1
Year and Date
2015-03-27 – 2015-03-28
Related Report
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[Presentation] Clinical features of schizophrenia with enhanced carbonyl stress2013
Author(s)
Mitsuhiro Miyashita, Makoto Araia, Akiko Koboria, Tomoe Ichikawaa, Kazuya Toriumia, Hiroko Yuzawab, Izumi Noharaa, Mayumi Araia, Nanako Obataa, Yuji Okazakic, Takeo Yoshikawad, Naoji Amanoe, Masanari Itokawa
Organizer
第11回世界生物学的精神医学会
Place of Presentation
京都
Related Report
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