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Investigation to elucidate the pathophysiology of schizophrenia using carbonyl stress biomarkers

Research Project

Project/Area Number 25861040
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionTokyo Metropolitan Institute of Medical Science (2015)
Shinshu University (2013-2014)

Principal Investigator

MIYASHITA Mitsuhiro  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (60532132)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsカルボニルストレス / 統合失調症 / ペントシジン / ビタミンB6 / 終末糖化産物
Outline of Final Research Achievements

We investigated reproducibility of enhanced carbonyl stress in another new larger cohort of schizophrenic patients. As a result of the investigation, we found significant increase of pentosidine levels and decrease of serum pyridoxal in schizophrenia, respectively when compared to those of control subjects. In addition, we found that patients with enhanced carbonyl stress shared many clinical features with treatment-resistant schizophrenia. These include a higher proportion of inpatients, longer durations of hospitalization, and higher doses of antipsychotic medication, compared with patients without carbonyl stress. Interestingly, psychopathological symptoms showed a tendency towards negative association with serum vitamin B6 levels. Our results support the idea that treatment regimes reducing carbonyl stress, such as supplementation of pyridoxamine, could provide novel therapeutic benefits for this subgroup of patients.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Characterization of modified proteins in plasma from a subtype of schizophrenia based on carbonyl stress: Protein carbonyl is a possible biomarker of psychiatric disorders.2015

    • Author(s)
      Koike S, Kayama T, Arai M, Horiuchi Y, Kobori A, Miyashita M, Itokawa M, Ogasawara Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 467 Issue: 2 Pages: 361-366

    • DOI

      10.1016/j.bbrc.2015.09.152

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Advanced glycation end products and schizophrenia: A systematic review.2015

    • Author(s)
      Kouidrat Y, Amad A, Arai M, Miyashita M, Lalau JD, Loas G, Itokawa M.
    • Journal Title

      J Psychiatr Res.

      Volume: 66-67 Pages: 112-117

    • DOI

      10.1016/j.jpsychires.2015.04.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] カルボニルストレス代謝障害と統合失調症2015

    • Author(s)
      新井誠、小堀晶子、宮下光弘、鳥海和也、堀内泰江、畠山幸子、内田美樹、井上智子、糸川昌成
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 26(1) Pages: 27-33

    • NAID

      130005395573

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Carbonyl stress inschizophrenia2014

    • Author(s)
      Itokawa M, Miyashita M, Arai M, Miyata T
    • Journal Title

      Biochem Soc Trans

      Volume: 42(2) Issue: 2 Pages: 468-72

    • DOI

      10.1042/bst20140044

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carbonyl stress and schizophrenia2014

    • Author(s)
      Makoto Aarai, Mitsuhiro Miyashita, Akiko Kobori, Kazuya Toriumi, Yasue Hoiuchi, and Masanari Itokawa
    • Journal Title

      Psychiatry and Clinical Neuroscience 2014

      Volume: 68 Issue: 9 Pages: 655-665

    • DOI

      10.1111/pcn.12216

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Replication of enhanced carbonyl stress in a subpopulation of schizophrenia2014

    • Author(s)
      Miyashita M, Arai M, Yuzawa H, Niizato K, Oshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 68 Issue: 1 Pages: 83-84

    • DOI

      10.1111/pcn.12081

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features of schizophrenia with enhanced carbonyl stress2014

    • Author(s)
      Miyashita M, Arai M, Kobori A, Ichikawa T, Toriumi K, Niizato K, Oshima, K, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M.
    • Journal Title

      Schizophr Bull.

      Volume: 40(5) Issue: 5 Pages: 1040-1046

    • DOI

      10.1093/schbul/sbt129

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] カルボニルストレスという代謝異常と統合失調症:体に負担の少ないビタミンB6による治療法の研究2013

    • Author(s)
      宮下光弘、新井誠、市川智恵、鳥海和也、小堀晶子、天野直二、糸川昌成
    • Journal Title

      総合病院精神医学

      Volume: 第25巻 (3) Pages: 254-261

    • NAID

      130006832757

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Pentosidene accumulation in the pathophysiology of Schizophrenia2015

    • Author(s)
      M Arai, Y Horiuchi, A Kobori, M Miyashita, K Toriumi, S Hashimoto, M Itokawa
    • Organizer
      Society for Neuroscience 45th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経炎症・酸化ストレスをキーワードにした精神疾患の理解:糖化・酸化ストレスと関連する統合失調症の病態研究2015

    • Author(s)
      新井誠. 堀内泰江、小堀晶子、鳥海和也、畠山幸子、宮下光弘、糸川昌成
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京都・江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical features of schizophrenia with enhanced carbonyl stress and potential therapeutic value of vitamin B62015

    • Author(s)
      Mitsuhiro Miyashita, Makoto Arai, Akiko Kobori, Yasue Horiuchi, Kazuya Toriumi, Tomoe Ichikawa, Kazuhiro Niizato, Kenichi Oshima, Yuji Okazaki, Takeo Yoshikawa, Naoji Amano, Toshio Miyata, Masanari Itokawa.
    • Organizer
      第10回日本統合失調症学会
    • Place of Presentation
      東京 都市センターホテル, 東京都千代田区平河町2-4-1
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] カルボニルストレスを呈する統合失調症の臨床特徴2013

    • Author(s)
      宮下光弘、新井 誠、小堀 晶子、市川 智恵、鳥海 和也、新井 麻友美、小幡 菜々子、野原 泉、大島 健一、新里 和弘、岡崎 祐士、吉川 武男、天野 直二、糸川 昌成
    • Organizer
      第8回統合失調症学会
    • Place of Presentation
      浦河、北海道
    • Related Report
      2013 Research-status Report
  • [Presentation] カルボニルストレス性統合失調症の臨床特徴2013

    • Author(s)
      宮下 光弘、新井 誠、市川 智恵、鳥海 和也、小堀 晶子、新井 麻友美、小幡 菜々子、岡崎 祐士、吉川 武男、天野 直二、糸川 昌成
    • Organizer
      第109回日本精神神経学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical features of schizophrenia with enhanced carbonyl stress2013

    • Author(s)
      Mitsuhiro Miyashita, Makoto Araia, Akiko Koboria, Tomoe Ichikawaa, Kazuya Toriumia, Hiroko Yuzawab, Izumi Noharaa, Mayumi Araia, Nanako Obataa, Yuji Okazakic, Takeo Yoshikawad, Naoji Amanoe, Masanari Itokawa
    • Organizer
      第11回世界生物学的精神医学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Book] 「メンタル医療~原因解明と診断、治療の最前線~」2013

    • Author(s)
      宮下光弘、新井誠、市川智恵、鳥海和也、小堀晶子、天野直二、糸川昌成
    • Total Pages
      200
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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