| Project/Area Number |
25861046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YASUDA Koichi 北海道大学, 医学(系)研究科(研究院), 特任助教 (00431362)
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| Research Collaborator |
NISHIKAWA Yukiko 北海道大学, 医学研究科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 低酸素イメージング / FMISO-PET / FMISO |
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| Outline of Final Research Achievements |
Although hypoxic cancer cell is shown to be radio-resistance in vitro and vivo, the clinical impact of cancer-hypoxia is not clear. Before radiation therapy, we performed FMISO-PET, which is one of hypoxia imagings. The locational relationship between the site of FMISO uptake and local relapse was examined. In the analysis of small voxel (1 x 1 x 2mm), it was indicated that the site with higher FMISO uptake had a higher probability of local recurrence than lower uptake in relapse patients. The simulation study of dose-escalation radiation therapy targeting hypoxic region was performed.
Some results of this research was published at the annual American Society of Radiation Oncology meeting, which is world-leading conference in radiation oncology.
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