Radiotherapy targeting hypoxic cancer cells: research for biologically appropriate method of dose delivery

• Project/Area Number: 25861046
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: YASUDA Koichi 北海道大学, 医学(系)研究科(研究院), 特任助教 (00431362)
• Research Collaborator: NISHIKAWA Yukiko 北海道大学, 医学研究科, 大学院生
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 低酸素イメージング / FMISO-PET / FMISO

Outline of Final Research Achievements

Although hypoxic cancer cell is shown to be radio-resistance in vitro and vivo, the clinical impact of cancer-hypoxia is not clear. Before radiation therapy, we performed FMISO-PET, which is one of hypoxia imagings. The locational relationship between the site of FMISO uptake and local relapse was examined. In the analysis of small voxel (1 x 1 x 2mm), it was indicated that the site with higher FMISO uptake had a higher probability of local recurrence than lower uptake in relapse patients. The simulation study of dose-escalation radiation therapy targeting hypoxic region was performed.
Some results of this research was published at the annual American Society of Radiation Oncology meeting, which is world-leading conference in radiation oncology.

Research Products

• [Presentation] The Voxel-based Analysis of [18F]FMISO-PET Image in Patients with Local Recurrence of Nasopharyngeal Carcinoma (2015)
  • Author(s): Yukiko Nishikawa, Koichi Yasuda, Shozo Okamoto, Yoichi M. Ito, Takashi Mori, Rikiya Onimaru, Tohru Shiga, Kazuhiko Tsuchiya, Shiro Watanabe, Wataru Takeuchi, Norio Katoh, Yuji Kuge, Nagara Tamaki, and Hiroki Shirato.
  • Organizer: 57th annual American Society for Radiation Oncology (ASTRO) Meeting
  • Place of Presentation: Henry B. Gonzalez Convention Center, San Antonio, Texas, USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] CTVがOARに近接する際にCTV-PTVマージンを狭く設定した場合の影響 (2014)
  • Author(s): 安田耕一、土屋和彦、鬼丸力也、原田八重、原田慶一、西川由記子、木下留美子、辻真太朗、堀田賢治、鈴木隆介、白土博樹
  • Organizer: 日本放射線腫瘍学会第27回学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] The Impact of FMISO-PET before treatment in Nasopharyngeal Cancer Patients. (2013)
  • Author(s): Koichi Yasuda, Kazuhiko Tsuchiya, Shozo Okamoto, Rikiya Onimaru, Tohru Shiga, Keiichi Harada, Ryusuke Suzuki, Yuji Kuge, Nagara Tamaki, and Hiroki Shirato.
  • Organizer: ASTRO 55th Annual meeting
  • Place of Presentation: Georgia World Congress Center, Atlanta, USA