| Project/Area Number |
25861054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
Monzen Satoru 弘前大学, 保健学研究科, 講師 (20514136)
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| Research Collaborator |
Mariya Yasushi 青森県むつ総合病院, 副院長 (20239148)
Hosokawa Yoichiro 弘前大学, 大学院保健学研究科, 教授 (70173599)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ラジオアイソトープ内用療法 / 治療予備能力 / 微小核発現細胞 / 酸化ストレス / 放射性ヨウ素 / 分化型甲状腺癌 / 放射線内用療法 / 放射線被ばく / バイオマーカー / 予備能力 / 末梢血 / 微小核 / 甲状腺関連ホルモン / バイオマーカ― |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the effect of radioisotope treatment on the extent of cytogenetic damage in lymphocytes and on the composition of the hematopoietic system, thyroid-related hormones and CD45+ cell cytotoxicity. 1st: On the patient analysis of radioactive iodine therapy (RIT) for ablation of differentiated thyroid carcinoma, it is suggested that the correlation between micronuclei frequency and the platelet system in peripheral blood may serve as a biomarker of exposure and, possibly, of sensitivity in DTC patients undergoing RIT following thyroid and lymph node surgery. 2nd: On the analysis of thyroid related hormone in peripheral blood, it was clarified that a higher concentration of thyroglobulin under abnormal conditions modifies radiation dose response of micronuclei frequency, and suggest that micronuclei frequency in cytogenetic dosimetry is affected by thyroid hormones.
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