A fundamental research for hybrid tracking radiotherapy without invasive metal marker

• Project/Area Number: 25861055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hirosaki University
• Principal Investigator: Hideo Kawaguchi 弘前大学, 医学部附属病院, 助教 (20587654)
• Research Collaborator: TAKAI Yoshihiro 弘前大学, 大学院医学研究科, 教授
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 放射線治療 / 定位放射線治療 / 動態追尾 / 呼吸移動 / 肺癌

Outline of Final Research Achievements

In this study, the motion of internal markers, external markers and others were measured by biplane fluoroscopic images at 0, 10 and 20 minutes. We found difficulty for prediction of tumor motion by external marker motion alone. The motion of external markers, diaphragms and ribs were delayed than that of internal markers in a moment, so they cannot be used as trigger signal. However, when they were combined, the respiratory phase can be grasped more accurately. As time passed, body sinking due to degree of tension of the muscles and body rotation due to crosswise difference of extended arm position were observed. Both DRR and fluoroscopic image were nearly matched, but not completely due to scan image attributes.

Research Products

• [Journal Article] Prognostic impact of average iodine density assessed by dual-energy spectral imaging for predicting lung tumor recurrence after stereotactic body radiotherapy. (2016)
  • Author(s): Masahiko Aoki, Katsumi Hirose, Mariko Sato, Hiroyoshi Akimoto, Hideo Kawaguchi, Yoshiomi Hatayama, Ichitaro Fujioka, Mitsuki Tanaka, Shuichi Ono, Yoshihiro Takai
  • Journal Title: Journal of radiation research Volume: 57 Issue: 4 Pages: 381-386
  • DOI: 10.1093/jrr/rrv100
  • Peer Reviewed / Open Access
• [Journal Article] Impact of pretreatment whole-tumor perfusion computed tomography and 18F-fluorodeoxyglucose positron emission tomography/computed tomography measurements on local control of non-small cell lung cancer treated with stereotactic body radiotherapy. (2016)
  • Author(s): Aoki M, Akimoto H, Sato M , Hirose K, Kawaguchi H , Hatayama Y, Seino H, Kakehata S, Tsushima F, Fujita H, Fujita T, Fujioka I, Tanaka M, Miura H, Ono S, Takai Y
  • Journal Title: Journal of Radiation Research Volume: 57 Issue: 5 Pages: 533-540
  • DOI: 10.1093/jrr/rrw045
  • Peer Reviewed / Open Access
• [Journal Article] Stereotactic body radiotherapy for lung metastases as oligo-recurrence: a single institutional study. (2016)
  • Author(s): Masahiko Aoki, Yoshiomi Hatayama, Hideo Kawaguchi, Katsumi Hirose, Mariko Sato, Hiroyoshi Akimoto, Hiroyuki Miura, Shuichi Ono, Yoshihiro Takai
  • Journal Title: Journal of radiation research Volume: 57 Issue: 1 Pages: 55-61
  • DOI: 10.1093/jrr/rrv063
  • Peer Reviewed / Open Access
• [Presentation] 骨シンチを行った前立腺癌症例における放射線治療適応の検討 (2017)
  • Author(s): 川口英夫、田中円葵、藤岡一太郎、秋本裕義、佐藤まり子、畑山佳臣、三浦弘行、青木昌彦、古家琢也、大山力
  • Organizer: 第21回青森前立腺癌研究会
  • Place of Presentation: ワラッセ（青森県・青森市）
• [Presentation] 北日本における甲状腺未分化癌の放射線治療成績 (2016)
  • Author(s): 川口英夫、青木昌彦、髙橋紀善、菊池光洋、佐藤久志、土屋和彦、安倍明、永倉久泰、黒田勇気、三輪弥沙子、髙井良尋、神宮啓一
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 国立京都国際会館（京都府・京都市）
  • Year and Date: 2016-11-25
• [Presentation] 頭頚部IMRTの初期経験 (2016)
  • Author(s): 川口英夫、田中円葵、藤岡一太郎、秋本裕義、佐藤まり子、畑山佳臣、青木昌彦、廣瀬勝己、髙井良尋
  • Organizer: 第22回北奥羽放射線治療懇話会
  • Place of Presentation: 八幡平ロイヤルホテル（岩手県・八幡平市）