Establishment of tumor blood flow imaging to predict the chemotherapy effect for lung caner
| Project/Area Number |
25861092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
Yanagawa Masahiro 大阪大学, 医学(系)研究科(研究院), 助教 (00546872)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肺癌 / 腫瘍血流 / 水PET/CT / VEGF / radioactive water PET/CT / Bevacizumab / lung cancer / Radioactive water PET / tumor perfusion |
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| Outline of Final Research Achievements |
The purpose of this study was to establish tumor blood flow imaging by evaluating tumor blood flow in patients with non small cell lung cancer (NSCLC) before and after treatment of (BEV) using 15O-water PET and CT perfusion. There was a significant difference between tumor blood flow before and after chemotherapy with BEV. Large decrease in blood flow early after treatment of BEV was associated with short time to tumor progression. The antiangeonenic therapy might not have benefit for the patients with tumor blood flow decrease early after BEV.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Monitoring Response to Antiangiogenic Therapy of Non-Small Cell Lung Cancer using 15O-water PET: the Relationship between Tumor Blood Flow and the Prognosis.2015
Author(s)
Yanagawa M, Matsunaga K, Kato H, Shimosegawa E, Honda O, Kijima T, Hirata H, Otsuka T, Kumanogoh A, Hatazawa J, Tomiyama N.
Organizer
Radiological Society of North America 101th Scientific Assembly and Annual Meeting.
Place of Presentation
Chicago, U.S.A.
Year and Date
2015-11-29
Related Report
Int'l Joint Research
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[Presentation] The latest Imaging Assessment for Anti-Tumor Therapy: therapeutic response for various tumors using PET/CT or PET/MRI.2014
Author(s)
Masahiro Yanagawa, Tadashi Watabe, Kayako Isohashi, Osamu Honda, Ken Ueda, Hiromitsu Sumikawa, Yukiihsa Satoh, Toru Kanazawa, Shojiro Hidaka, Maki Masada, Jun Hatazawa, Noriyuki Tomiyama
Organizer
Radiological Society of North America 100th Scientific Assembly and Annual Meeting.
Place of Presentation
Chicago(U.S.A)
Year and Date
2014-11-30 – 2014-12-05
Related Report
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[Presentation] PET using H215O in non-small cell lung cancer: quantitative evaluation of antiangiogenic therapy effects.2014
Author(s)
Masahiro Yanagawa, Keiko Matsunaga, Hiroshi Watabe, Eku Shimosegawa, Koiichi Fujino, Hiroki Kato, Ken Ueda, Yukihisa Satoh, Toru Kanazawa, Shojiro Hidaka, Hiromitsu Sumikawa, Osamu Honda, Takashi Kijima, Jun Hatazawa, Noriyuki Tomiyama
Organizer
The 73nd Annual Meeting of the Japan Radiological Society.
Place of Presentation
横浜
Year and Date
2014-04-10 – 2014-04-13
Related Report
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