Establishment of tumor blood flow imaging to predict the chemotherapy effect for lung caner

• Project/Area Number: 25861092
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: Yanagawa Masahiro 大阪大学, 医学(系)研究科(研究院), 助教 (00546872)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 肺癌 / 腫瘍血流 / 水PET/CT / VEGF / radioactive water PET/CT / Bevacizumab / lung cancer / Radioactive water PET / tumor perfusion

Outline of Final Research Achievements

The purpose of this study was to establish tumor blood flow imaging by evaluating tumor blood flow in patients with non small cell lung cancer (NSCLC) before and after treatment of (BEV) using 15O-water PET and CT perfusion. There was a significant difference between tumor blood flow before and after chemotherapy with BEV. Large decrease in blood flow early after treatment of BEV was associated with short time to tumor progression. The antiangeonenic therapy might not have benefit for the patients with tumor blood flow decrease early after BEV.

Research Products

• [Presentation] Monitoring Response to Antiangiogenic Therapy of Non-Small Cell Lung Cancer using 15O-water PET: the Relationship between Tumor Blood Flow and the Prognosis. (2015)
  • Author(s): Yanagawa M, Matsunaga K, Kato H, Shimosegawa E, Honda O, Kijima T, Hirata H, Otsuka T, Kumanogoh A, Hatazawa J, Tomiyama N.
  • Organizer: Radiological Society of North America 101th Scientific Assembly and Annual Meeting.
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Change in thyroid gland perfusion after anti-VEGF therapy studied by means of 15O-H2O PET (2015)
  • Author(s): 松永恵子、梁川雅弘、渡部浩司、藤埜浩一、加藤弘樹、下瀬川恵久、畑澤順
  • Organizer: 第55回日本核医学会学術総会
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2015-11-05
• [Presentation] 肺癌血流の画像学的定量解析：CT perfusion & Radioactive water-PETの臨床応用 (2015)
  • Author(s): 梁川雅弘
  • Organizer: 第8回横断的腫瘍フォーラム
  • Place of Presentation: Osaka, Japan.
  • Year and Date: 2015-07-06
• [Presentation] Dynamic 水PET/CT：Monitoring Response to Antiangiogenic Therapy of Non-Small Cell Lung Cancer: the Relationship between Tumor Blood Flow and the Prognosis (2015)
  • Author(s): 梁川 雅弘
  • Organizer: 第6回Anti-Angiogenesis Biomarker conference
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-06
• [Presentation] 肺癌の画像診断 Update： 見る、観る、診る (2015)
  • Author(s): 梁川 雅弘
  • Organizer: 第18回関西 Radiology Update 講演会
  • Place of Presentation: 大阪
  • Year and Date: 2015-03-14
• [Presentation] The latest Imaging Assessment for Anti-Tumor Therapy: therapeutic response for various tumors using PET/CT or PET/MRI. (2014)
  • Author(s): Masahiro Yanagawa, Tadashi Watabe, Kayako Isohashi, Osamu Honda, Ken Ueda, Hiromitsu Sumikawa, Yukiihsa Satoh, Toru Kanazawa, Shojiro Hidaka, Maki Masada, Jun Hatazawa, Noriyuki Tomiyama
  • Organizer: Radiological Society of North America 100th Scientific Assembly and Annual Meeting.
  • Place of Presentation: Chicago(U.S.A)
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] PET using H215O in non-small cell lung cancer: quantitative evaluation of antiangiogenic therapy effects. (2014)
  • Author(s): Masahiro Yanagawa, Keiko Matsunaga, Hiroshi Watabe, Eku Shimosegawa, Koiichi Fujino, Hiroki Kato, Ken Ueda, Yukihisa Satoh, Toru Kanazawa, Shojiro Hidaka, Hiromitsu Sumikawa, Osamu Honda, Takashi Kijima, Jun Hatazawa, Noriyuki Tomiyama
  • Organizer: The 73nd Annual Meeting of the Japan Radiological Society.
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] PET using H215O in non-small cell lung cancer: quantitative evaluation of antiangiogenic therapy effects (2014)
  • Author(s): Masahiro Yanagawa, Keiko Matsunaga, Hiroshi Watabe, Eku Shimoegawa, Kouichi Fujino, Hiroki Kato, Ken Ueda, Yukihisa Sato, Toru Kanazawa, Shojiro Hidaka
  • Organizer: The 73st Annual Meeting of Japan Radiological Society
  • Place of Presentation: 横浜、東京
• [Presentation] Monitoring response to antiangiogenic therapy of non-small cell lung cancer using 15O-water and PET. (2013)
  • Author(s): Keiko Matsunaga, Hiroshi Watabe, Masahiro Yanagawa, Kouichi Fujino, Hiroki Kato, Eku Shimosegawa, Jun Hatazawa
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2013 Anuual meeting
  • Place of Presentation: Vancouver, BC, Canada
• [Book] Nuclear Oncology Chapter 32: Assessment of Response to Antitumor Treatment (2014)
  • Author(s): Masahiro Yanagawa, Noriyuki Tomiyama, Tadashi Watabe, Kayako Isohashi, and Jun Hatazawa
  • Publisher: Lippincott Williams & Wilkins