Quantitative evaluation and imaging of intratumoral oxygen metabolism by O-15 oxygen PET
| Project/Area Number |
25861095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
WATABE Tadashi 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 (90648932)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 腫瘍 / 低酸素 / 酸素代謝 / 血流 / PET / FMISO / O15 / O-15ガス |
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| Outline of Final Research Achievements |
The purpose of this study was to evaluate the intratumoral perfusion and oxygen metabolism in hypoxic regions in the rat xenograft model. Six male Fischer rats with C6 glioma were investigated with 18F-FMISO PET and steady state inhalation method of 15O-gas PET. The tumoral blood flow (TBF), tumoral metabolic rate of oxygen (TMRO2), oxygen extraction fraction (OEF), and tumoral blood volume (TBV) were measured under artificial ventilation with 15O-CO2, 15O-O2, and 15O-CO gases. Intratumoral hypoxic regions showed significantly lower TBF, higher OEF, lower TMRO2, and lower TBV values than non-hypoxic regions. This study demonstrated intratumoral hypoxic regions showed decreased blood flow with an increased OEF, suggesting the need for a treatment strategy to normalize the blood flow for oxygen-avid active tumor cells in hypoxic regions.
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Report
(3 results)
Research Products
(15 results)
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[Presentation] Quantitative PET imaging of intratumoral oxygen metabolism in hypoxic lesions: comparison study of 18F-FMISO and 15O-labeled gas inhalation PET.2014
Author(s)
Watabe T, Kanai Y, Ikeda H, Horitsugi G, Matsunaga K, Kato H, Isohashi K, Abe K, Shimosegawa E, Hatazawa J
Organizer
Annual Congress of the European Association of Nuclear Medicine (EANM 2014)
Place of Presentation
Gothernburg, Sweden
Year and Date
2014-10-18 – 2014-10-23
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[Presentation] Quantitative PET imaging of intratumoral oxygen metabolism by 15O-labeled gas inhalation PET.2014
Author(s)
Watabe T, Horitsugi G, Kanai Y, Ikeda H, Kato H, Hanaoka K, Naka S, Isohashi K, Shimosegawa E, Hatazawa J
Organizer
Society of Nuclear Medicine and Molecular Imaging's 61th Annual Meeting (SNMMI 2014)
Place of Presentation
St Louis, USA
Year and Date
2014-06-07 – 2014-06-12
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[Book] Nuclear Oncology2014
Author(s)
Masahiro Yanagawa, Noriyuki Tomiyama, Tadashi Watabe, Kayako Isohashi, Jun Hatazawa
Total Pages
16
Publisher
Springer
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