Effectiveness of bone marrow sparing IMRT using FLT-PET

• Project/Area Number: 25861097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: ISOHASHI Fumiaki 大阪大学, 医学(系)研究科(研究院), 准教授 (00448036)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 放射線治療学 / 急性期有害事象 / 骨髄抑制 / 放射線治療

Outline of Final Research Achievements

Pelvic radiotherapy contributes significantly to the development of hematologic toxicity (HT). More than one-half of the body's bone marrow is located in pelvic bones. To purpose of this study was to evaluate bone marrow sparing intensity modulated radiotherapy (IMRT). The main results of this study as follows;
Patients treated with bowel sparing IMRT had a higher incidence of acute HT. The volume of the pelvic bone receiving relatively high-dose (V40-45 Gy) radiation is associated with acute HT. In conclusion, techniques to limit the pelvic bone irradiation may reduce acute HT.

Research Products

• [Journal Article] Dose-volume analysis of predictors for chronic gastrointestinal complications in patients with cervical cancer treated with postoperative concurrent chemotherapy and whole-pelvic radiation therapy (2016)
  • Author(s): Isohashi F, Mabuchi S, Akino Y, Yoshioka Y, Seo Y, Suzuki O, Tamari K, Yoshino K, Sawada K, Ueda Y, Kobayashi E, Sumida I, Mizuno Y, Okubo H, Kimura T, Ogawa K.
  • Journal Title: J Radiat Res Volume: 未定
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Intensity-modulated radiation therapy versus three-dimensional conformal radiation therapy with concurrent nedaplatin-based chemotherapy after radical hysterectomy for uterine cervical cancer: comparison of outcomes, complications, and dose-volume histogram parameters. (2015)
  • Author(s): Isohashi F, Mabuchi S, Yoshioka Y, Seo Y, Suzuki O, Tamari K, Yamashita M, Unno H, Kinosa Y, Kozasa K, Sumida I, Otani Y, Kimura T, Ogawa K.
  • Journal Title: Radiat Oncol Volume: 10 Issue: 1 Pages: 180-180
  • DOI: 10.1186/s13014-015-0486-5
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Dose-volume analysis of predictors for chronic gastrointestinal complications in patients with cervical cancer treated with postoperative concurrent chemotherapy and whole-pelvic radiation therapy (2015)
  • Author(s): 礒橋文明、玉利慶介、高橋 豊、隅田伊織、鈴木 修、瀬尾雄二、吉岡靖生、小川和彦
  • Organizer: 第28回日本放射線腫瘍学会
  • Place of Presentation: ベイシア文化ホール（群馬県・前橋市）
  • Year and Date: 2015-11-20
• [Presentation] Intensity-modulated radiation therapy versus three-dimensional conformal radiation therapy with concurrent nedaplatin-based chemotherapy after radical hysterectomy for uterine cervical cancer: comparison of outcomes, complications, and dose-volume histogram parameters (2015)
  • Author(s): Isohashi F, Mabuchi S, Yoshioka Y, Seo Y, Suzuki O, Tamari K, Yamashita M, Unno H, Kinose Y, Kozasa K, Sumida I, Otani Y, Kimura T, Ogawa K.
  • Organizer: International congress of radiation research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-26
• [Presentation] Dose-volume analysis of predictors for acute hematologic toxicity in patients with cervical cancer treated with postoperative pelvic radiation therapy and concurrent nedaplatin-based chemotherapy (2014)
  • Author(s): Isohashi F, Yoshioka Y, Mabuchi S, Seo Y, Suzuki O, Sumida I, Otani Y, Kimura T, Ogawa K.
  • Organizer: ASTRO 56th annual meeting
  • Place of Presentation: San Francisco