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Development of PET imaging modality for increasing the radiation treatment efficiency of the malignant tumor

Research Project

Project/Area Number 25861099
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

ISOHASHI KAYAKO  大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) (50598604)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsPET / 放射線治療 / 悪性腫瘍 / PET/CT / MRI / 治療効果 / 代謝
Outline of Final Research Achievements

Malignant tumor is non-uniform. Within malignant tumor, sensitive sites and low portions of the radiation are mixed.In order to increase the radiation therapy efficiency, localization and radiation therapy effect of tumor cells is required to estimate the site can be expected. In this study, metabolism images with PET-CT and morphological images with CT/MRI in the malignant head and neck tumor of the human and the small animal were compared and evaluated. These images were also compared with the pathological tissue and subsequent clinical course. We aim to establish a image evaluation system for the selection of high PET-CT diagnosis and treatment methods of further precision.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Prognostic Value of FDG-PET, Based on the Revised Response Criteria, in Patients with Malignant Lymphoma: A Comparison with CT/MRI Evaluations, Based on the International Working Group/ Cotswolds Meeting Criteria2015

    • Author(s)
      Kayako Isohashi; Mitsuaki Tatsumi; Hiroki Kato; Kentaro Fukushima; Tetsuo Maeda; Tadashi Watabe; Eku Shimosegawa; Yuzuru Kanakura; Jun Hatazawa
    • Journal Title

      Asia Oceania Journal of Nuclear Medicine and Biology

      Volume: 3 Pages: 91-98

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat.2014

    • Author(s)
      Watabe T, Naka S, Ikeda H, Horitsugi G, Kanai Y, Isohashi K, Ishibashi M, Kato H, Shimosegawa E, Watabe H, Hatazawa J.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 9 Pages: 116-116

    • DOI

      10.1371/journal.pone.0107427

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] FBPA-PETの全身動態分布2015

    • Author(s)
      礒橋佳也子、下瀬川恵久、加藤弘樹、堀次元気、仲定宏、金井泰和、持田郁子、渡部直史、巽光朗、畑澤順
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      ハイアットリージェンシー東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳房専用装置PEMGRAPHの使用経験2015

    • Author(s)
      礒橋佳也子、伊藤正敏、馬場 護、熊谷和明、伊藤繁記、佐藤弘樹、山本誠一、畑澤順
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      ハイアットリージェンシー東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Dynamic whole body distribution of FBPA in humans studied with 3D PET/CT2015

    • Author(s)
      Isohashi K, Shimosegawa E, Kato H, Horitsugi G, Naka S, Kanai Y, Mochida I, Watabe T, Tatsumi M, Hatazawa J.
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine (EANM’15).
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of the T / B ratio in healthy volunteers and tumor patients.2015

    • Author(s)
      Isohashi K, Kato H, Horitsugi G, Naka S, Kanai Y, Mochida I, Watabe T, Tatsumi M, Shimosegawa E, Hatazawa J.
    • Organizer
      第12回日本中性子補足療法学会学術大会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Early treatment effects with anti-CD20 immunotherapy in aggressive non-Hodgkin lymphoma: Histopathological, MR-based morphometric, and FDG PET/CT-based metabolic studies in nude rats.2014

    • Author(s)
      礒橋佳也子
    • Organizer
      EANM 2014
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] FBPA-PETの標準化に向けて2014

    • Author(s)
      礒橋佳也子
    • Organizer
      第47回近畿核医学地方会
    • Place of Presentation
      神戸大学医学部附属病院医学部会館シスメックスホール
    • Year and Date
      2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] FBPA-PETの標準化2014

    • Author(s)
      礒橋佳也子
    • Organizer
      第13回日本中性子捕捉療法学会
    • Place of Presentation
      大阪大学
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Prognostic value of imaging diagnosis on CT/MRI with International Working Group Criteria (IWC) and FDG-PET with Revised Response Criteria (RRC) in patients with malignant lymphoma (ML)2013

    • Author(s)
      Kayako Isohashi, et al.
    • Organizer
      the SNMMI 2013 Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] 原発性肺癌または縦隔嚢胞性腫瘍における胸部リンパ節域の異常集積の評 価:MET PET/CTとFDG PET/CTとの比較

    • Author(s)
      礒橋佳也子 等
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性リンパ腫における分子標的治療薬の効果判定の基礎的研究

    • Author(s)
      礒橋佳也子 等
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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