| Project/Area Number |
25861114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HORI Masakazu 札幌医科大学, 医学部, 助教 (90404714)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 放射線治療 / 食道癌 / DNA修復 / 放射線増刊 / オラパリブ / PARP阻害剤 |
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| Outline of Final Research Achievements |
Olaparip, a PARP inhibitor had the radiosensitizing effects in as low concentrations as 0.05μM, that is clinically attainable. In esophageal cancer, the higher expression of XRCC4 indicated the significantly deteriorated local control and overall survival, suggesting that the inhibition of DNA repair may be effective to improve treatments results of esophageal cancer. Olaparib could be promising in the treatment of esophageal cancer as a radionsensitizer. Further researches are required.
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